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Three hundred and ninety-eight patients with disseminated solid tumors other than breast cancer, were treated with a combination chemotherapy protocol utilizing cyclophosphamide, vincristine sulfate, methotrexate, 5-fluorouracil, and prednisone. Three hundred and eighty were evaluable (95.5%). Partial or complete tumor regressions were noted in 73 of 380 (19%) evaluable patients. Response to therapy was associated with a prolongation and survival. The largest tumor categories were lung, ovary, and gastrointestinal. The proportion of complete plus partial responses in evaluable lung cancer patients was 40/236 (17%), compared to 20/44 (45%) for ovarian cancer patients and 6/39 (15%) for gastrointestinal tumors. Of the patients who could be evaluated for toxicity, 47% had minimal or no toxicity, 51% had moderate to severe toxicity, and 2% had life threatening toxicity. Virtually all patients were treated and managed as outpatients.
J D Bearden, and
C A Coltman, and
T E Moon, and
J J Costanzi, and
J H Saiki, and
S P Balcerzak, and
S E Rivkin, and
F S Morrison, and
M Lane, and
S C Spigel
March 1969,
Cancer,
J D Bearden, and
C A Coltman, and
T E Moon, and
J J Costanzi, and
J H Saiki, and
S P Balcerzak, and
S E Rivkin, and
F S Morrison, and
M Lane, and
S C Spigel
February 1971,
The American journal of the medical sciences,
J D Bearden, and
C A Coltman, and
T E Moon, and
J J Costanzi, and
J H Saiki, and
S P Balcerzak, and
S E Rivkin, and
F S Morrison, and
M Lane, and
S C Spigel
January 1985,
Acta radiologica. Oncology,
J D Bearden, and
C A Coltman, and
T E Moon, and
J J Costanzi, and
J H Saiki, and
S P Balcerzak, and
S E Rivkin, and
F S Morrison, and
M Lane, and
S C Spigel
January 1973,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
J D Bearden, and
C A Coltman, and
T E Moon, and
J J Costanzi, and
J H Saiki, and
S P Balcerzak, and
S E Rivkin, and
F S Morrison, and
M Lane, and
S C Spigel
October 1984,
American journal of clinical oncology,
J D Bearden, and
C A Coltman, and
T E Moon, and
J J Costanzi, and
J H Saiki, and
S P Balcerzak, and
S E Rivkin, and
F S Morrison, and
M Lane, and
S C Spigel
May 1984,
Cancer,
J D Bearden, and
C A Coltman, and
T E Moon, and
J J Costanzi, and
J H Saiki, and
S P Balcerzak, and
S E Rivkin, and
F S Morrison, and
M Lane, and
S C Spigel
January 1987,
Cancer investigation,
J D Bearden, and
C A Coltman, and
T E Moon, and
J J Costanzi, and
J H Saiki, and
S P Balcerzak, and
S E Rivkin, and
F S Morrison, and
M Lane, and
S C Spigel
August 1976,
Sovetskaia meditsina,
J D Bearden, and
C A Coltman, and
T E Moon, and
J J Costanzi, and
J H Saiki, and
S P Balcerzak, and
S E Rivkin, and
F S Morrison, and
M Lane, and
S C Spigel
January 1973,
Tumori,
J D Bearden, and
C A Coltman, and
T E Moon, and
J J Costanzi, and
J H Saiki, and
S P Balcerzak, and
S E Rivkin, and
F S Morrison, and
M Lane, and
S C Spigel
January 1977,
Progress in clinical and biological research,
