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This paper reviews the changing concepts in the treatment of patients with malignant melanoma localized on the arm or leg. In addition to conventional surgical treatment, isolated regional perfusion of the extremities is discussed. An evaluation is presented of clinical and histological criteria applied to determine indications for conventional surgical treatment and for perfusion. It is maintained that isolated regional perfusion of arm or leg should be performed when the primary tumor meets one of the following criteria: (1) depth of tumor invasion beyond the papillary layer (Clark levels III, IV and V); (2) vascular invasion; (3) tumor diameter exceeding 1 cm; (4) ulceration. If none of these four criteria applies, conventional surgical treatment alone has proved to give very good results.
H Schraffordt Koops, and
J Oldhoff, and
E van der Ploeg, and
A Vermey, and
R Eibergen, and
H Beekhuis
October 1961,
Plastic and reconstructive surgery and the transplantation bulletin,
H Schraffordt Koops, and
J Oldhoff, and
E van der Ploeg, and
A Vermey, and
R Eibergen, and
H Beekhuis
December 1965,
Cancer,
H Schraffordt Koops, and
J Oldhoff, and
E van der Ploeg, and
A Vermey, and
R Eibergen, and
H Beekhuis
December 1978,
Lakartidningen,
H Schraffordt Koops, and
J Oldhoff, and
E van der Ploeg, and
A Vermey, and
R Eibergen, and
H Beekhuis
February 1962,
Cancer chemotherapy reports,
H Schraffordt Koops, and
J Oldhoff, and
E van der Ploeg, and
A Vermey, and
R Eibergen, and
H Beekhuis
May 1963,
American journal of surgery,
H Schraffordt Koops, and
J Oldhoff, and
E van der Ploeg, and
A Vermey, and
R Eibergen, and
H Beekhuis
April 1996,
American journal of surgery,
H Schraffordt Koops, and
J Oldhoff, and
E van der Ploeg, and
A Vermey, and
R Eibergen, and
H Beekhuis
March 1984,
Surgery, gynecology & obstetrics,
H Schraffordt Koops, and
J Oldhoff, and
E van der Ploeg, and
A Vermey, and
R Eibergen, and
H Beekhuis
September 1970,
Minerva medica,
H Schraffordt Koops, and
J Oldhoff, and
E van der Ploeg, and
A Vermey, and
R Eibergen, and
H Beekhuis
January 1977,
Acta chirurgica Scandinavica,
H Schraffordt Koops, and
J Oldhoff, and
E van der Ploeg, and
A Vermey, and
R Eibergen, and
H Beekhuis
June 1965,
Ortopediia travmatologiia i protezirovanie,
