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Dietary protein provokes renal growth and synthesis of renin. Because angiotensin II (AII) has growth-promoting properties, we tested the possibility that protein-induced renal growth depends on angiotensin II. Normal adult male rats placed on a high-protein diet (50%) developed significant renal and glomerular growth over 6 days compared with rats on a low-protein diet (6%). However, neither angiotensin converting enzyme inhibition with enalapril nor angiotensin receptor antagonism with losartan influenced the degree of whole-kidney, cortical tubular, or glomerular growth. Thus, angiotensin II is not a necessary factor in dietary protein-induced renal growth in normal adult rats.
L J Smith, and
M E Rosenberg, and
T H Hostetter
February 1977,
Circulation research,
L J Smith, and
M E Rosenberg, and
T H Hostetter
October 2000,
Hypertension (Dallas, Tex. : 1979),
L J Smith, and
M E Rosenberg, and
T H Hostetter
January 2013,
Current pharmaceutical design,
L J Smith, and
M E Rosenberg, and
T H Hostetter
April 1997,
Journal of the American Society of Nephrology : JASN,
L J Smith, and
M E Rosenberg, and
T H Hostetter
October 1994,
Kidney international,
L J Smith, and
M E Rosenberg, and
T H Hostetter
January 1998,
Basic research in cardiology,
L J Smith, and
M E Rosenberg, and
T H Hostetter
July 1986,
Kidney international,
L J Smith, and
M E Rosenberg, and
T H Hostetter
October 1986,
Hypertension (Dallas, Tex. : 1979),
L J Smith, and
M E Rosenberg, and
T H Hostetter
September 1975,
The American journal of physiology,
L J Smith, and
M E Rosenberg, and
T H Hostetter
December 1998,
Kidney international,
