Biomaterial Database

Effects of continuous wave and pulsed laser on blood coagulation. An in vitro thromboelastographic study. 1993

H O Savolainen

Department of Thoracic and Cardiovascular Surgery, Helsinki University Central Hospital.

Besides being thrombogenic, lasers may have direct adverse effects on different constituents of blood itself, when used intraluminally in angioplasty. This pilot study was therefore designed to examine the effect of continuous wave (CW Nd: YAG) and pulsed wave (XeCl excimer) laser irradiation on whole blood coagulation and fibrinolysis in vitro using thromboelastography (TEG). TEG showed shortened reaction and coagulation times after three and six seconds with 10 W of continuous wave laser irradiation of 10 ml of blood. The clot formation rate and maximal amplitude were decreased with CW laser and the plasma clot lysis at one hour was significantly increased (P < 0.05). The effect of the pulsed wave laser was less pronounced. The exposure of whole blood to laser irradiation accelerated coagulation and enhanced fibrinolysis. The clinical significance of the findings is to be settled since the thrombogenicity of lasers is mainly caused by their effect on the vessel wall and thereby the on platelet-wall interaction.

UI	MeSH Term	Description	Entries
D011517	Prothrombin Time	Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS.	Quick Test,Russell's Viper Venom Time,Thrombotest,Russell Viper Venom Time,Russells Viper Venom Time,Prothrombin Times,Test, Quick,Time, Prothrombin,Times, Prothrombin
D012016	Reference Values	The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.	Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D001777	Blood Coagulation	The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.	Blood Clotting,Coagulation, Blood,Blood Clottings,Clotting, Blood
D001779	Blood Coagulation Factors	Endogenous substances, usually proteins, that are involved in the blood coagulation process.	Clotting Factor,Coagulation Factors,Blood Coagulation Factor,Clotting Factors,Coagulation Factor,Coagulation Factor, Blood,Coagulation Factors, Blood,Factor, Coagulation,Factors, Coagulation,Factor, Blood Coagulation,Factor, Clotting,Factors, Blood Coagulation,Factors, Clotting
D006452	Hemoglobinometry	Measurement of hemoglobin concentration in blood.	Hemoglobinometries
D006461	Hemolysis	The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	Haemolysis,Extravascular Hemolysis,Intravascular Hemolysis,Extravascular Hemolyses,Haemolyses,Hemolyses, Extravascular,Hemolyses, Intravascular,Hemolysis, Extravascular,Hemolysis, Intravascular,Intravascular Hemolyses
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013916	Thrombelastography	Use of a thrombelastograph, which provides a continuous graphic record of the physical shape of a clot during fibrin formation and subsequent lysis.	Thromboelastography,Thromboelastometry
D016342	Angioplasty, Laser	A technique utilizing a laser coupled to a catheter which is used in the dilatation of occluded blood vessels. This includes laser thermal angioplasty where the laser energy heats up a metal tip, and direct laser angioplasty where the laser energy directly ablates the occlusion. One form of the latter approach uses an EXCIMER LASER which creates microscopically precise cuts without thermal injury. When laser angioplasty is performed in combination with balloon angioplasty it is called laser-assisted balloon angioplasty (ANGIOPLASTY, BALLOON, LASER-ASSISTED).	Laser Angioplasty,Angioplasties, Laser,Laser Angioplasties