Evaluating exposure cutpoint bias in epidemiologic studies of electric and magnetic fields. 1993

D Wartenberg, and D A Savitz
Department of Environmental & Community Medicine, UMDNJ-Robert Wood Johnson Medical School, Piscataway 08854.

Epidemiologists who study the association between exposure to electric or magnetic fields and adverse health outcomes often classify their subjects as "exposed" and "unexposed," and they report results based on an odds ratio. The exposure classification rule--or dichotomy rule--is typically based on a priori assumptions or arbitrary considerations. We show that results may vary substantially with selection of different cutpoints by which to dichotomize exposure. Further, interpretation and comparison of studies is dependent on the choice of cutpoint. We suggest the use of probability plots as a more informative method of data representation. To demonstrate the utility of probability plots, we re-analyze data reported by Savitz et al. [1988, Am J Epidemiol 128:21-38]. Using a higher exposure cutpoint than that of the original analysis, we obtained larger odds ratios, two of which achieved statistical significance. More important, probability plots of these data showed 1) consistency of results with measures of magnetic fields in both low- and high-power-use situations, and 2) discordance with results based on measures of electric fields. Given these observations, we recommend further study, especially that focused on the most highly exposed individuals.

UI MeSH Term Description Entries
D004574 Electromagnetic Fields Fields representing the joint interplay of electric and magnetic forces. Electromagnetic Field,Field, Electromagnetic,Fields, Electromagnetic
D004781 Environmental Exposure The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals. Exposure, Environmental,Environmental Exposures,Exposures, Environmental
D004812 Epidemiologic Methods Research techniques that focus on study designs and data gathering methods in human and animal populations. Epidemiologic Method,Epidemiological Methods,Methods, Epidemiologic,Epidemiological Method,Method, Epidemiologic,Method, Epidemiological,Methods, Epidemiological
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015982 Bias Any deviation of results or inferences from the truth, or processes leading to such deviation. Bias can result from several sources: one-sided or systematic variations in measurement from the true value (systematic error); flaws in study design; deviation of inferences, interpretations, or analyses based on flawed data or data collection; etc. There is no sense of prejudice or subjectivity implied in the assessment of bias under these conditions. Aggregation Bias,Bias, Aggregation,Bias, Ecological,Bias, Statistical,Bias, Systematic,Ecological Bias,Outcome Measurement Errors,Statistical Bias,Systematic Bias,Bias, Epidemiologic,Biases,Biases, Ecological,Biases, Statistical,Ecological Biases,Ecological Fallacies,Ecological Fallacy,Epidemiologic Biases,Experimental Bias,Fallacies, Ecological,Fallacy, Ecological,Scientific Bias,Statistical Biases,Truncation Bias,Truncation Biases,Bias, Experimental,Bias, Scientific,Bias, Truncation,Biase, Epidemiologic,Biases, Epidemiologic,Biases, Truncation,Epidemiologic Biase,Error, Outcome Measurement,Errors, Outcome Measurement,Outcome Measurement Error

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