Synthesis of some new 4,6-disubstituted-1,2,4-triazin-3,5(2H) diones and related compounds of potential antifungal activity. 1993

R M Abdel-Rahman, and M Seada, and Z el-Gendy, and I E Islam, and M B Mahmoud
Chemistry Department, Faculty of Education, Ain Shams University, Roxy, Cairo, Egypt.

The synthesis of 4-substituted amino-6-styryl/alkyl/aryl-1,2,4-triazin- 3,5(2H)diones (4a-d and 15) involving the cyclocondensation of N4-arylaminosemicarbazides(3a-d and 13) with some alpha-ketoacids is described. The behaviour of these triazinones towards amine, hydrazine, isothiocyanate, aromatic aldehyde and gl. acetic acid have been investigated. Structure elucidation of the new compounds has been carried out with the help of elemental analysis, IR, UV and 1H-NMR spectra. The antifungal activity of the prepared compounds has been assayed both in vitro and in vivo against some phytopathogenic fungi associated with wheat grains, were the compound 3b showed a high protection of the grains of wheat against the fungal infection.

UI MeSH Term Description Entries
D008826 Microbial Sensitivity Tests Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D005658 Fungi A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies. Fungi, Filamentous,Molds,Filamentous Fungi,Filamentous Fungus,Fungus,Fungus, Filamentous,Mold
D005659 Fungicides, Industrial Chemicals that kill or inhibit the growth of fungi in agricultural applications, on wood, plastics, or other materials, in swimming pools, etc. Industrial Fungicides
D014227 Triazines Heterocyclic rings containing three nitrogen atoms, commonly in 1,2,4 or 1,3,5 or 2,4,6 formats. Some are used as HERBICIDES. Triazine,Benzotriazines
D014908 Triticum A plant genus of the family POACEAE that is the source of EDIBLE GRAIN. A hybrid with rye (SECALE CEREALE) is called TRITICALE. The seed is ground into FLOUR and used to make BREAD, and is the source of WHEAT GERM AGGLUTININS. Wheat,Durum Wheat,Triticum aestivum,Triticum durum,Triticum spelta,Triticum turgidum,Triticum turgidum subsp. durum,Triticum vulgare,Durum Wheats,Wheat, Durum

Related Publications

R M Abdel-Rahman, and M Seada, and Z el-Gendy, and I E Islam, and M B Mahmoud
November 2008, Archiv der Pharmazie,
R M Abdel-Rahman, and M Seada, and Z el-Gendy, and I E Islam, and M B Mahmoud
January 2006, Arzneimittel-Forschung,
R M Abdel-Rahman, and M Seada, and Z el-Gendy, and I E Islam, and M B Mahmoud
September 2018, SLAS discovery : advancing life sciences R & D,
R M Abdel-Rahman, and M Seada, and Z el-Gendy, and I E Islam, and M B Mahmoud
January 2001, European journal of medicinal chemistry,
R M Abdel-Rahman, and M Seada, and Z el-Gendy, and I E Islam, and M B Mahmoud
November 2017, Molecules (Basel, Switzerland),
R M Abdel-Rahman, and M Seada, and Z el-Gendy, and I E Islam, and M B Mahmoud
June 2006, Bioorganic & medicinal chemistry letters,
R M Abdel-Rahman, and M Seada, and Z el-Gendy, and I E Islam, and M B Mahmoud
January 2015, Pest management science,
R M Abdel-Rahman, and M Seada, and Z el-Gendy, and I E Islam, and M B Mahmoud
January 2012, Zeitschrift fur Naturforschung. C, Journal of biosciences,
R M Abdel-Rahman, and M Seada, and Z el-Gendy, and I E Islam, and M B Mahmoud
April 2008, Organic & biomolecular chemistry,
R M Abdel-Rahman, and M Seada, and Z el-Gendy, and I E Islam, and M B Mahmoud
January 1997, Acta poloniae pharmaceutica,
Copied contents to your clipboard!