Biomaterial Database

Variation in the susceptibility of Bacteroides fragilis group isolates from six Chicago hospitals. 1993

D W Hecht, and J R Osmolski, and J P O'Keefe

Department of Medicine, Loyola University Chicago, Maywood, Illinois 60153.

The antimicrobial susceptibility of isolates of the Bacteroides fragilis group from six hospitals in the Chicago area varied from one institution to another; this variation was similar to the geographic variation documented in a national survey. A total of 365 B. fragilis group isolates were tested against 10 antibiotics. Imipenem, piperacillin/tazobactam, ampicillin/sulbactam, ticarcillin/clavulanate, and cefoperazone/sulbactam had excellent activity against all members of the B. fragilis group, with little interhospital variation. Cefoxitin and ceftizoxime had very good activity, also with little variation among hospitals. Clindamycin, cefotetan, and cefmetazole had the lowest level of activity, with unusually high-level resistance confined to three of the six hospitals. These data indicate that variation in the antimicrobial susceptibility of these bacteria is likely based in the hospital rather than in the geographic region and that the in vitro activity of certain antibiotics against B. fragilis group isolates from individual hospitals cannot be predicted from the data obtained in larger-scale surveys.

UI	MeSH Term	Description	Entries
D008826	Microbial Sensitivity Tests	Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).	Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D002641	Chicago	A city in Illinois.
D004352	Drug Resistance, Microbial	The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).	Antibiotic Resistance,Antibiotic Resistance, Microbial,Antimicrobial Resistance, Drug,Antimicrobial Drug Resistance,Antimicrobial Drug Resistances,Antimicrobial Resistances, Drug,Drug Antimicrobial Resistance,Drug Antimicrobial Resistances,Drug Resistances, Microbial,Resistance, Antibiotic,Resistance, Drug Antimicrobial,Resistances, Drug Antimicrobial
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000046	Academic Medical Centers	Medical complexes consisting of medical school, hospitals, clinics, libraries, administrative facilities, etc.	Medical Centers, Academic,Medical Centers, University,University Medical Centers,Academic Medical Center,Center, Academic Medical,Center, University Medical,Centers, Academic Medical,Centers, University Medical,Medical Center, Academic,Medical Center, University,University Medical Center
D001439	Bacteroides	A genus of gram-negative, anaerobic, rod-shaped bacteria. Its organisms are normal inhabitants of the oral, respiratory, intestinal, and urogenital cavities of humans, animals, and insects. Some species may be pathogenic.
D001441	Bacteroides fragilis	Gram-negative bacteria occurring in the lower intestinal tracts of man and other animals. It is the most common species of anaerobic bacteria isolated from human soft tissue infections.
D001442	Bacteroides Infections	Infections with bacteria of the genus BACTEROIDES.	Infections, Bacteroides,Bacteroides Infection,Infection, Bacteroides
D013045	Species Specificity	The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.	Species Specificities,Specificities, Species,Specificity, Species
D016304	Hospitals, Private	A class of hospitals that includes profit or not-for-profit hospitals that are controlled by a legal entity other than a government agency. (Hospital Administration Terminology, AHA, 2d ed)	Private Hospitals,Hospital, Private,Private Hospital