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Enhanced incorporation of 1-beta-D-arabinofuranosylcytosine by pretreatment with etoposide. 1993
K Ooi, and
T Ohkubo, and
H Kuwabara, and
M Higashigawa, and
H Kawasaki, and
H Kakitoh, and
Y Kagawa, and
S Inagaki, and
K Sumida, and
M Sakurai
Department of Pharmacy, Social Insurance Hazu Hospital, Mie-Ken, Japan.
We examined the effects of timing of administration of etoposide on cytosine arabinoside (ara-C) incorporation into DNA in L1210 ascites tumor. At 1 hr after injection of ara-C, 3-hr and 6-hr pretreatments with 15 mg/kg of etoposide increased ara-C incorporation to more than 200% as compared to that of ara-C given alone. Simultaneous administration of etoposide, however, decreased ara-C incorporation to 33% of that of ara-C alone. These results might explain the previously reported sequence dependency of the antitumor effect of etoposide and ara-C.
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