Biomaterial Database

NG-methyl-L-arginine restores arterial pressure in hemorrhaged rats. 1993

R E Klabunde, and K J Slayton, and R C Ritger

Department of Pharmacology, Abbott Laboratories, Abbott Park, IL 60064.

NG-methyl-L-arginine (NMA) has been shown to inhibit nitric oxide production in vascular endothelium in vitro, and to cause vascular constriction and pressor responses in vivo. This study evaluated the ability of NMA to restore arterial pressure in hemorrhaged rats in order to determine the role of nitric oxide in modulating vascular tone following hemorrhage. Rats were anesthetized with pentobarbital, and hemorrhaged (0.5 ml/min/100 g body weight for 2 min) to a pressure of 41 +/- 4 mm Hg (control 111 +/- 5 mm Hg). Five minutes after ending the hemorrhage, administration of NMA (30 mg/kg, i.v.) caused rapid and complete restoration of arterial pressure, due primarily to increased systemic vascular resistance. Administration of L-arginine before NMA greatly attenuated the pressor response to NMA. NMA caused similar pressor responses in nonhemorrhaged rats, which were also partially blocked by L-arginine. Cardiac output was transiently increased by NMA in hemorrhaged, but not in nonhemorrhaged, animals. These results support the hypothesis that endothelial nitric oxide production has a significant modulatory effect on vascular tone during hemorrhage, and that inhibition of nitric oxide production permits greater expression of vasoconstrictor influences.

UI	MeSH Term	Description	Entries
D007022	Hypotension	Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.	Blood Pressure, Low,Hypotension, Vascular,Low Blood Pressure,Vascular Hypotension
D008297	Male		Males
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001120	Arginine	An essential amino acid that is physiologically active in the L-form.	Arginine Hydrochloride,Arginine, L-Isomer,DL-Arginine Acetate, Monohydrate,L-Arginine,Arginine, L Isomer,DL Arginine Acetate, Monohydrate,Hydrochloride, Arginine,L Arginine,L-Isomer Arginine,Monohydrate DL-Arginine Acetate
D001158	Arteries	The vessels carrying blood away from the heart.	Artery
D012771	Shock, Hemorrhagic	Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.	Hemorrhagic Shock
D014655	Vascular Resistance	The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.	Peripheral Resistance,Total Peripheral Resistance,Pulmonary Vascular Resistance,Systemic Vascular Resistance,Peripheral Resistance, Total,Resistance, Peripheral,Resistance, Pulmonary Vascular,Resistance, Systemic Vascular,Resistance, Total Peripheral,Resistance, Vascular,Vascular Resistance, Pulmonary,Vascular Resistance, Systemic
D017207	Rats, Sprague-Dawley	A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.	Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats