BIOMAT Database Logo BIOMAT Database Logo

Age-dependent alterations in vascular smooth muscle cell responsiveness to platelet-derived growth factor in genetic hypertension. 1993

J Saltis, and A Agrotis, and A Bobik
Baker Medical Research Institute, Alfred Hospital, Prahran, Victoria, Australia.

1. This study examined and compared the growth characteristics of vascular smooth muscle cells (VSMC) isolated from 4 and 12 week old spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats following stimulation with platelet-derived growth factor-BB (PDGF-BB). 2. Vascular smooth muscle cells from 4 week old SHR proliferated at a slower rate than VSMC isolated from 12 week old SHR (1.08 +/- 0.06/day vs 1.89 +/- 0.13/day respectively, P < 0.05). In contrast, there was no difference in the proliferation of VSMC from 4 and 12 week WKY rats (0.62 +/- 0.06/day vs 0.82 +/- 0.13/day, respectively, P > 0.05). 3. The cell density at which VSMC from 4 and 12 week old SHR become refractory to the mitogenic effects of PDGF-BB was similar and approximately two-fold greater than VSMC from age-matched WKY rats. 4. This study concludes that there is an age-dependent, differential and specific upregulation of growth rate mechanisms in VSMC from SHR which enhance proliferation in response to PDGF-BB.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D009131 Muscle, Smooth, Vascular The nonstriated involuntary muscle tissue of blood vessels. Vascular Smooth Muscle,Muscle, Vascular Smooth,Muscles, Vascular Smooth,Smooth Muscle, Vascular,Smooth Muscles, Vascular,Vascular Smooth Muscles
D010982 Platelet-Derived Growth Factor Mitogenic peptide growth hormone carried in the alpha-granules of platelets. It is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication. Platelet Derived Growth Factor,Factor, Platelet-Derived Growth,Growth Factor, Platelet-Derived
D011918 Rats, Inbred SHR A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke. Rats, Spontaneously Hypertensive,Rats, SHR,Inbred SHR Rat,Inbred SHR Rats,Rat, Inbred SHR,Rat, SHR,Rat, Spontaneously Hypertensive,SHR Rat,SHR Rat, Inbred,SHR Rats,SHR Rats, Inbred,Spontaneously Hypertensive Rat,Spontaneously Hypertensive Rats
D011921 Rats, Inbred WKY A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR). Rats, Wistar Kyoto,Wistar Kyoto Rat,Rats, WKY,Inbred WKY Rat,Inbred WKY Rats,Kyoto Rat, Wistar,Rat, Inbred WKY,Rat, WKY,Rat, Wistar Kyoto,WKY Rat,WKY Rat, Inbred,WKY Rats,WKY Rats, Inbred,Wistar Kyoto Rats
D002455 Cell Division The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION. M Phase,Cell Division Phase,Cell Divisions,Division Phase, Cell,Division, Cell,Divisions, Cell,M Phases,Phase, Cell Division,Phase, M,Phases, M
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001011 Aorta The main trunk of the systemic arteries. Aortas

Related Publications

J Saltis, and A Agrotis, and A Bobik
Vascular smooth muscle cell hyper-responsiveness to growth factors in hypertension.
December 1988, Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
J Saltis, and A Agrotis, and A Bobik
Platelet-derived growth factor-induced alterations in vinculin distribution in porcine vascular smooth muscle cells.
January 1987, Cell motility and the cytoskeleton,
J Saltis, and A Agrotis, and A Bobik
Aspirin enhances platelet-derived growth factor-induced vascular smooth muscle cell proliferation.
April 1997, Journal of vascular surgery,
J Saltis, and A Agrotis, and A Bobik
Two platelet-derived growth factor receptors in vascular smooth muscle cells.
October 1991, Japanese circulation journal,
J Saltis, and A Agrotis, and A Bobik
Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function.
September 2008, Molecular and cellular biology,
J Saltis, and A Agrotis, and A Bobik
[The research progress in platelet-derived growth factor -mediated vascular smooth muscle cell function].
October 2015, Sheng li ke xue jin zhan [Progress in physiology],
J Saltis, and A Agrotis, and A Bobik
Platelet-derived endothelial cell growth factor inhibits DNA synthesis in vascular smooth muscle cells.
September 1999, American journal of hypertension,
J Saltis, and A Agrotis, and A Bobik
Platelet-derived growth factor stimulates LAT1 gene expression in vascular smooth muscle: role in cell growth.
April 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
J Saltis, and A Agrotis, and A Bobik
Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension.
January 2020, Pulmonary circulation,
J Saltis, and A Agrotis, and A Bobik
Platelet-derived growth factor stimulated vascular smooth muscle cell proliferation and its molecular mechanism.
April 2000, Acta pharmacologica Sinica,
Copied contents to your clipboard!