Biomaterial Database

The effects of arachidonic acid in isolated atria of guinea pigs. 1977

J Borbola, and K Süsskand, and M Siess, and L Szekeres

The effects of free and albumin-bound arachidonic acid, which is the precursor of the prostaglandins E2 and F2alpha, were studied on the spontaneous rate, contractile force and myocardial fatty acid metabolism in isolated, spontaneously beating atria of guinea pigs. Both free and albumin-bound arachidonic acid (10(-6)-10(-3) M) produced a dose-dependent positive chronotropic and a modest inotropic action. Tachyphylaxis to the positive chronotropic action of arachidonic acid developed in the course of repeated applications. Beta-Adrenoceptor blockade (pincolol) and pretreatment with reserpine or prostaglandin-synthetase inhibitors (indomethacin, fenoprofen, aspirin, 5,8,11,14-eicosatetraynoic acid) failed to affect the chronotropic activity of arachidonic acid significantly. The action of arachidonic acid was independent of the decarboxylation of the fatty acid. Linoleic and oleic acids did not show any positive chronotropic activity. The data are interpreted as suggesting that changes induced by arachidonic acid might be partly due to peroxides formed from arachidonic acid.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009200	Myocardial Contraction	Contractile activity of the MYOCARDIUM.	Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D009206	Myocardium	The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.	Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D009921	Metaproterenol	A beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM.	Orciprenaline,Alotec,Alupent,Astmopent,Metaprel,Metaproterenol Polistirex,Metaproterenol Sulfate,Orciprenaline Sulfate,Polistirex, Metaproterenol
D010869	Pindolol	A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)	Prindolol,LB-46,Visken,LB 46,LB46
D011453	Prostaglandins	A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.	Prostaglandin,Prostanoid,Prostanoids
D011485	Protein Binding	The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.	Plasma Protein Binding Capacity,Binding, Protein
D012110	Reserpine	An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.	Raunervil,Raupasil,Rausedil,Rausedyl,Serpasil,Serpivite,V-Serp,V Serp
D004347	Drug Interactions	The action of a drug that may affect the activity, metabolism, or toxicity of another drug.	Drug Interaction,Interaction, Drug,Interactions, Drug
D005231	Fatty Acids, Unsaturated	FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds.	Fatty Acids, Polyunsaturated,Polyunsaturated Fatty Acid,Unsaturated Fatty Acid,Polyunsaturated Fatty Acids,Acid, Polyunsaturated Fatty,Acid, Unsaturated Fatty,Acids, Polyunsaturated Fatty,Acids, Unsaturated Fatty,Fatty Acid, Polyunsaturated,Fatty Acid, Unsaturated,Unsaturated Fatty Acids