Biomaterial Database

Aminopeptidases: towards a mechanism of action. 1993

A Taylor

Laboratory for Nutrition, USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111.

Aminopeptidases catalyse the removal of amino acids from peptide substrates. Although many functions have been ascribed to these enzymes, lack of knowledge of their complex structure has prevented detailed analysis. Several recent studies have now provided information on the structure and molecular biology of these enzymes, the kinetics of substrate hydrolysis and inhibitor binding. These new data allow prediction of a model mechanism of action for a large subgroup of aminopeptidases.

UI	MeSH Term	Description	Entries
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000626	Aminopeptidases	A subclass of EXOPEPTIDASES that act on the free N terminus end of a polypeptide liberating a single amino acid residue. EC 3.4.11.	Aminopeptidase
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013329	Structure-Activity Relationship	The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.	Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships