-transparent.png){kind=logo}
A 10-min bilateral carotid occlusion (BCO) in a control group of Mongolian gerbils, induced a transient generalized epileptic activity both in the hippocampal and in the cortical regions, associated with motor manifestations. After recirculation, spiking activity persisted, reaching its maximum peak within 18-36 h and then slowly decreasing till its total disappearance on the 6th-7th day. On the 7th day, histological studies manifested a selective loss of CA1 hippocampal neurons. The treated gerbils (divided in 2 groups according to the dosage used) were administered clonazepam (CZP), a benzodiazepine receptor agonist, immediately after clamping and again every 24 h for the following three days at dosages of 0.05 and 0.1 mg/kg i.p., respectively. The drug inhibited epileptic activity in a dose-dependent manner, while it prevented CA1 neuronal loss at both doses. These results point to a possible derangement of the GABAergic system which probably in turn triggers an exaggerated excitation.
M G Marciani, and
G Santone, and
G Sancesario, and
R Massa, and
P Stanzione, and
G Bernardi
January 2007,
Indian journal of physiology and pharmacology,
M G Marciani, and
G Santone, and
G Sancesario, and
R Massa, and
P Stanzione, and
G Bernardi
January 1983,
Neuropatologia polska,
M G Marciani, and
G Santone, and
G Sancesario, and
R Massa, and
P Stanzione, and
G Bernardi
June 2003,
BMC pharmacology,
M G Marciani, and
G Santone, and
G Sancesario, and
R Massa, and
P Stanzione, and
G Bernardi
December 1988,
Stroke,
M G Marciani, and
G Santone, and
G Sancesario, and
R Massa, and
P Stanzione, and
G Bernardi
January 2001,
Brain research,
M G Marciani, and
G Santone, and
G Sancesario, and
R Massa, and
P Stanzione, and
G Bernardi
June 1989,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
M G Marciani, and
G Santone, and
G Sancesario, and
R Massa, and
P Stanzione, and
G Bernardi
January 2013,
Acta neurochirurgica. Supplement,
M G Marciani, and
G Santone, and
G Sancesario, and
R Massa, and
P Stanzione, and
G Bernardi
March 1994,
Japanese journal of pharmacology,
M G Marciani, and
G Santone, and
G Sancesario, and
R Massa, and
P Stanzione, and
G Bernardi
March 1992,
Acta neurologica Scandinavica,
M G Marciani, and
G Santone, and
G Sancesario, and
R Massa, and
P Stanzione, and
G Bernardi
April 1995,
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology,
