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In order to investigate some potential accumulate properties of hydroxylated PCB metabolites, blood and tissues such as livers, kidneys, lungs and adipose tissue from rats exposed to a commercial PCB (Aroclor 1254) were analyzed for hydroxylated PCBs (OH-PCBs). A large number of OH-PCBs were detected in the liver 1 day after exposure among which almost 13 have been identified in the blood. OH-PCBs were retained selectively in the blood probably due to binding between the OH-PCBs and a protein in serum. One major OH-PCB determined in rat blood was 4-OH-2', 3, 3', 4', 5-pentaCB formed from 2, 3, 3', 4, 4'-pentaCB after NIH shift. Blood of a grey seal from the Baltic also contained at least 8 OH-PCB congeners with 2 major compounds determined as 4-OH-2', 3, 3', 4', 5-pentaCB and 4-OH-2, 3, 3', 4', 5, 5'-hexaCB. Thus, 4-OH-2', 3, 3', 4', 5-pentaCB is the most retainable OH-PCB congener in blood from rats and seal. Human serum have also been found to contain a few number of OH-PCBs at concentration of 0.6 ng/g serum which corresponds to one fourth of PCB level.
H Kuroki, and
K Haraguchi, and
H Saito, and
Y Masuda, and
E K Wehler, and
A Bergman
May 1994,
Environmental health perspectives,
H Kuroki, and
K Haraguchi, and
H Saito, and
Y Masuda, and
E K Wehler, and
A Bergman
January 2002,
Archives of environmental contamination and toxicology,
H Kuroki, and
K Haraguchi, and
H Saito, and
Y Masuda, and
E K Wehler, and
A Bergman
December 2001,
Chemosphere,
H Kuroki, and
K Haraguchi, and
H Saito, and
Y Masuda, and
E K Wehler, and
A Bergman
May 2005,
Ambio,
H Kuroki, and
K Haraguchi, and
H Saito, and
Y Masuda, and
E K Wehler, and
A Bergman
September 2002,
Environmental health perspectives,
H Kuroki, and
K Haraguchi, and
H Saito, and
Y Masuda, and
E K Wehler, and
A Bergman
September 2004,
The Science of the total environment,
H Kuroki, and
K Haraguchi, and
H Saito, and
Y Masuda, and
E K Wehler, and
A Bergman
November 2002,
Bulletin of environmental contamination and toxicology,
H Kuroki, and
K Haraguchi, and
H Saito, and
Y Masuda, and
E K Wehler, and
A Bergman
September 2021,
The Science of the total environment,
H Kuroki, and
K Haraguchi, and
H Saito, and
Y Masuda, and
E K Wehler, and
A Bergman
July 2017,
Toxicology letters,
H Kuroki, and
K Haraguchi, and
H Saito, and
Y Masuda, and
E K Wehler, and
A Bergman
March 2011,
Chemosphere,
