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The case of a female patient with acute lymphoblastic leukaemia and chronic disseminated candidiasis, who was refractory to 1.8 g conventional amphotericin B therapy, is reported. She experienced severe amphotericin-B-related side-effects in spite of pretreatment, but was subsequently successfully treated with 3 g of a small unilamellar liposome formulation of amphotericin B prepared from soya phosphatidylcholine and cholesterol in a 7:3 molar ratio at our institute. The patient experienced minimal side-effects with this preparation, although no pretreatment was given. Liposomal amphotericin B prepared in our institute appears to be a safe and effective therapy for systemic fungal infections. However, large controlled studies are required to determine more precisely the potential of liposomal amphotericin B in the treatment of severe systemic fungal infection.
P C Gokhale, and
R J Barapatre, and
S H Advani, and
N A Kshirsagar, and
S K Pandya
November 2002,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
P C Gokhale, and
R J Barapatre, and
S H Advani, and
N A Kshirsagar, and
S K Pandya
August 1991,
Journal of internal medicine,
P C Gokhale, and
R J Barapatre, and
S H Advani, and
N A Kshirsagar, and
S K Pandya
December 1992,
Irish journal of medical science,
P C Gokhale, and
R J Barapatre, and
S H Advani, and
N A Kshirsagar, and
S K Pandya
April 1999,
Mycoses,
P C Gokhale, and
R J Barapatre, and
S H Advani, and
N A Kshirsagar, and
S K Pandya
April 1992,
The Journal of infectious diseases,
P C Gokhale, and
R J Barapatre, and
S H Advani, and
N A Kshirsagar, and
S K Pandya
January 1994,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
P C Gokhale, and
R J Barapatre, and
S H Advani, and
N A Kshirsagar, and
S K Pandya
January 1998,
The Journal of infection,
P C Gokhale, and
R J Barapatre, and
S H Advani, and
N A Kshirsagar, and
S K Pandya
January 1985,
Annals of internal medicine,
P C Gokhale, and
R J Barapatre, and
S H Advani, and
N A Kshirsagar, and
S K Pandya
February 1987,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
P C Gokhale, and
R J Barapatre, and
S H Advani, and
N A Kshirsagar, and
S K Pandya
May 2004,
Indian pediatrics,
