Biomaterial Database

Dietary carnitine and adipose tissue turnover rate in exercise trained rats. 1977

E W Askew, and A L Hecker, and W R Wise

Rats trained by 12 weeks of treadmill running were divided into two groups and fed a control diet or an identical diet supplemented with 0.5% L-carnitine. Adipose tissue fatty acid turnover was subsequently estimated by an odd-carbon fatty acid enrichment method utilizing undecanoate as a marker representative of adipose tissue fatty acids. Compared to sedentary untrained control rats, exercise training increased perirenal adipose tissue turnover rate approximately 70%. Trained rats fed the carnitine supplemented diet did not exhibit any further increase in turnover rate. Neither [1-14C]palmitate oxidation by skeletal muscle homogenates nor palmitycarnitine acyl-transferase activity in skeletal muscle mitochondria was affected by carnitine feeding. The results of this study indicate that exercise training increases the turnover rate of adipose tissue fatty acids, but supplemental dietary carnitine does not. Under the conditions of this study, endogenous skeletal muscle carnitine levels in trained rats appear to be adequate to support the rate of fatty acids oxidation incurred by daily treadmill running.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D010169	Palmitic Acids	A group of 16-carbon fatty acids that contain no double bonds.	Acids, Palmitic
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D002331	Carnitine	A constituent of STRIATED MUSCLE and LIVER. It is an amino acid derivative and an essential cofactor for fatty acid metabolism.	Bicarnesine,L-Carnitine,Levocarnitine,Vitamin BT,L Carnitine
D002334	Carnitine O-Palmitoyltransferase	An enzyme that catalyzes reversibly the conversion of palmitoyl-CoA to palmitoylcarnitine in the inner mitochondrial membrane. EC 2.3.1.21.	Carnitine Palmitoyltransferase,CPT II,Carnitine Acyltransferase I,Carnitine Palmitoyltransferase I,Carnitine Palmitoyltransferase II,Palmitoylcarnitine Transferase,Palmitylcarnitine Acyltransferase,Acyltransferase I, Carnitine,Acyltransferase, Palmitylcarnitine,Carnitine O Palmitoyltransferase,II, Carnitine Palmitoyltransferase,O-Palmitoyltransferase, Carnitine,Palmitoyltransferase I, Carnitine,Palmitoyltransferase II, Carnitine,Palmitoyltransferase, Carnitine,Transferase, Palmitoylcarnitine
D004032	Diet	Regular course of eating and drinking adopted by a person or animal.	Diets
D005082	Physical Exertion	Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.	Physical Effort,Effort, Physical,Efforts, Physical,Exertion, Physical,Exertions, Physical,Physical Efforts,Physical Exertions
D005227	Fatty Acids	Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)	Aliphatic Acid,Esterified Fatty Acid,Fatty Acid,Fatty Acids, Esterified,Fatty Acids, Saturated,Saturated Fatty Acid,Aliphatic Acids,Acid, Aliphatic,Acid, Esterified Fatty,Acid, Saturated Fatty,Esterified Fatty Acids,Fatty Acid, Esterified,Fatty Acid, Saturated,Saturated Fatty Acids