Biomaterial Database

Quick estimation of kinetic parameters for a compartment with exponential absorption rate and first-order elimination rate. 1977

C D Thron

Two methods are presented for the quick estimation of kinetic parameters for a compartment with an exponential absorption rate and a first-order elimination rate. The first method is by direct computation from the observed levels of substance in the compartment at times t. 2t, and 3t, where t is arbitrary. The second method uses a numerical table to estimate the parameters from the observed peak level, the time of the peak level (or the time when the level rises to half on the peak level), and the time when the level has declined to half of its peak value. Some approximation equations also are given.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D008722	Methods	A series of steps taken in order to conduct research.	Techniques,Methodological Studies,Methodological Study,Procedures,Studies, Methodological,Study, Methodological,Method,Procedure,Technique
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D004364	Pharmaceutical Preparations	Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.	Drug,Drugs,Pharmaceutical,Pharmaceutical Preparation,Pharmaceutical Product,Pharmaceutic Preparations,Pharmaceutical Products,Pharmaceuticals,Preparations, Pharmaceutical,Preparation, Pharmaceutical,Preparations, Pharmaceutic,Product, Pharmaceutical,Products, Pharmaceutical
D000042	Absorption	The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.