BIOMAT Database Logo BIOMAT Database Logo

Urinary metabolites of pinacidil: I. Isolation and identification of the metabolites in rat urine. 1993

K Sakamoto, and Y Nakamura
Kanzakigawa Laboratory, Shionogi Research Laboratories, Shionogi & Co. Ltd., Osaka, Japan.

1. The urinary metabolites of pinacidil administered orally to rats, were analysed by h.p.l.c. Seven metabolites were isolated from rat urine following fractionation on an HP-20 column and purified by t.l.c. 2. The major metabolite was pinacidil-pyridine-N-oxide (M-1). omega-Hydroxypinacidil (M-2) and dealkylpinacidil (M-3) were less abundant metabolites, and minor metabolites were the M-2-aldehyde, in which an intramolecular ring had formed (M-4), M-2-pyridine-N-oxide (M-5), carbamoyl-pinacidil (M-7) and M-7-pyridine-N-oxide (M-6). 3. Metabolic pathways of pinacidil in rats were postulated from the isolated metabolites.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D002851 Chromatography, High Pressure Liquid Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed. Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D006146 Guanidines A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001711 Biotransformation The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
D013058 Mass Spectrometry An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers. Mass Spectroscopy,Spectrometry, Mass,Spectroscopy, Mass,Spectrum Analysis, Mass,Analysis, Mass Spectrum,Mass Spectrum Analysis,Analyses, Mass Spectrum,Mass Spectrum Analyses,Spectrum Analyses, Mass
D014665 Vasodilator Agents Drugs used to cause dilation of the blood vessels. Vasoactive Antagonists,Vasodilator,Vasodilator Agent,Vasodilator Drug,Vasorelaxant,Vasodilator Drugs,Vasodilators,Vasorelaxants,Agent, Vasodilator,Agents, Vasodilator,Antagonists, Vasoactive,Drug, Vasodilator,Drugs, Vasodilator
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

K Sakamoto, and Y Nakamura
Biotransformation of mazindol. I. Isolation and identification of some metabolites from rat urine.
January 1976, Drug metabolism and disposition: the biological fate of chemicals,
K Sakamoto, and Y Nakamura
Isolation and identification of eight procyclidine metabolites from rat urine.
December 1982, Archives internationales de pharmacodynamie et de therapie,
K Sakamoto, and Y Nakamura
Isolation and identification of eight procyclidine metabolites from rat urine.
January 1984, European journal of drug metabolism and pharmacokinetics,
K Sakamoto, and Y Nakamura
Isolation and identification of ten metabolites of breviscapine in rat urine.
July 2007, Biological & pharmaceutical bulletin,
K Sakamoto, and Y Nakamura
Isolation and identification of novel metabolites of gemfibrozil in rat urine.
January 1999, Drug metabolism and disposition: the biological fate of chemicals,
K Sakamoto, and Y Nakamura
Human moricizine metabolism. I. Isolation and identification of metabolites in human urine.
February 1997, Xenobiotica; the fate of foreign compounds in biological systems,
K Sakamoto, and Y Nakamura
Isolation and identification of two hydroxylated metabolites of phenazopyridine in rat urine.
June 1977, Il Farmaco; edizione scientifica,
K Sakamoto, and Y Nakamura
Biotransformation of the antidepressant DL-rolipram. I. Isolation and identification of metabolites from rat, monkey, and human urine.
January 1993, Drug metabolism and disposition: the biological fate of chemicals,
K Sakamoto, and Y Nakamura
Isolation and identification of three urinary metabolites of retinoic acid in the rat.
September 1976, Helvetica chimica acta,
K Sakamoto, and Y Nakamura
Biotransformation of trithiozine. III - Isolation and identification of further metabolites in rat urine.
September 1977, Il Farmaco; edizione scientifica,
Copied contents to your clipboard!