-transparent.png){kind=logo}
The spinal cords from eight autopsy cases of sporadic motor neuron disease (MND) and two control cases were immunohistochemically examined using antibodies directed to neurofilament proteins (anti-Nf) and to heparan sulfate (HepSS-1). Variable numbers of spheroids were observed in the anterior horns in the MND cases. In one case of MND, one third to half of the remaining anterior horn cells contained conglomerate inclusions in their perikarya. These pathological structures were not encountered in the control cases. The immunohistochemical study revealed that both anti-Nf and HepSS-1 intensely labelled all spheroids and conglomerate inclusions in the MND cases. The colocalization of heparan sulfate with neurofilamentous accumulation suggests that heparan sulfate is required for the aggregation of neurofilaments, resulting in the formation of spheroids and conglomerate inclusions in MND.
T Kato, and
T Katagiri, and
Y Shikama, and
K Kurita, and
I Toyoshima, and
A Hirano, and
M Wada, and
H Sasaki
December 2002,
Neuropathology : official journal of the Japanese Society of Neuropathology,
T Kato, and
T Katagiri, and
Y Shikama, and
K Kurita, and
I Toyoshima, and
A Hirano, and
M Wada, and
H Sasaki
September 1995,
Journal of neuropathology and experimental neurology,
T Kato, and
T Katagiri, and
Y Shikama, and
K Kurita, and
I Toyoshima, and
A Hirano, and
M Wada, and
H Sasaki
January 2014,
BioMed research international,
T Kato, and
T Katagiri, and
Y Shikama, and
K Kurita, and
I Toyoshima, and
A Hirano, and
M Wada, and
H Sasaki
May 1997,
Journal of neurology, neurosurgery, and psychiatry,
T Kato, and
T Katagiri, and
Y Shikama, and
K Kurita, and
I Toyoshima, and
A Hirano, and
M Wada, and
H Sasaki
September 1996,
Journal of neurology, neurosurgery, and psychiatry,
T Kato, and
T Katagiri, and
Y Shikama, and
K Kurita, and
I Toyoshima, and
A Hirano, and
M Wada, and
H Sasaki
April 1997,
Journal of neurology, neurosurgery, and psychiatry,
T Kato, and
T Katagiri, and
Y Shikama, and
K Kurita, and
I Toyoshima, and
A Hirano, and
M Wada, and
H Sasaki
February 2013,
Neurologic clinics,
T Kato, and
T Katagiri, and
Y Shikama, and
K Kurita, and
I Toyoshima, and
A Hirano, and
M Wada, and
H Sasaki
January 1992,
Acta anatomica,
T Kato, and
T Katagiri, and
Y Shikama, and
K Kurita, and
I Toyoshima, and
A Hirano, and
M Wada, and
H Sasaki
May 2023,
Life (Basel, Switzerland),
T Kato, and
T Katagiri, and
Y Shikama, and
K Kurita, and
I Toyoshima, and
A Hirano, and
M Wada, and
H Sasaki
October 1995,
Annals of neurology,
