-transparent.png){kind=logo}
The structure of the previously reported new antiinflammatory agent (1, FK3311) was chemically modified in an attempt to find novel compounds with more potent and broader-spectrum activities. Some 2'-(phenylthio) and 2'-(phenylamino)methanesulfonanilides (2 and 3), in particular those bearing an electron-attracting substituent at the 4'-position, potently inhibited adjuvant arthritis in rats as well as collagen-induced arthritis in mice when administered orally. 4'-Carbamoyl-2'-(2,4-difluorophenylthio)methanesulfonanilide (3b), which was selected as a candidate for further development from among the compounds synthesized herein, exhibited activity in reducing arthritis in a spontaneous autoimmune disease model (MRL/lpr mice) within the dose range of 10-100 mg/kg (p.o.).
K Nakamura, and
K Tsuji, and
N Konishi, and
H Okumura, and
M Matsuo
February 1983,
Journal of medicinal chemistry,
K Nakamura, and
K Tsuji, and
N Konishi, and
H Okumura, and
M Matsuo
April 1984,
Chemical & pharmaceutical bulletin,
K Nakamura, and
K Tsuji, and
N Konishi, and
H Okumura, and
M Matsuo
May 1984,
Il Farmaco; edizione scientifica,
K Nakamura, and
K Tsuji, and
N Konishi, and
H Okumura, and
M Matsuo
October 1992,
Farmaco (Societa chimica italiana : 1989),
K Nakamura, and
K Tsuji, and
N Konishi, and
H Okumura, and
M Matsuo
November 1983,
Chemical & pharmaceutical bulletin,
K Nakamura, and
K Tsuji, and
N Konishi, and
H Okumura, and
M Matsuo
December 1999,
Pharmaceutica acta Helvetiae,
K Nakamura, and
K Tsuji, and
N Konishi, and
H Okumura, and
M Matsuo
February 1989,
Farmaco (Societa chimica italiana : 1989),
K Nakamura, and
K Tsuji, and
N Konishi, and
H Okumura, and
M Matsuo
October 1969,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
K Nakamura, and
K Tsuji, and
N Konishi, and
H Okumura, and
M Matsuo
January 1980,
Annales pharmaceutiques francaises,
K Nakamura, and
K Tsuji, and
N Konishi, and
H Okumura, and
M Matsuo
December 1968,
Chemical & pharmaceutical bulletin,
