Biomaterial Database

Extensive osteolysis around an aseptic, stable, uncemented total knee replacement. 1993

D J Berry, and L E Wold, and J A Rand

Department of Orthopedics, Mayo Clinic, Rochester, Minnesota 55905.

Extensive osteolysis occurred around an aseptic, well-fixed, stable, uncemented total knee prosthesis. At the time of revision, tibial polyethylene wear and minimal metal-on-metal contact were present. A hypertrophic synovium-like membrane abutted bone in regions of osteolysis. Examination of this membrane revealed polyethylene-wear debris and significant levels of chromium, cobalt, and titanium. Wear debris--polyethylene, metal, or a combination of both--may be responsible for the osteolytic process in this case.

UI	MeSH Term	Description	Entries
D007720	Knee Prosthesis	Replacement for a knee joint.	Knee Prostheses,Prostheses, Knee,Prosthesis, Knee
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010014	Osteolysis	Dissolution of bone that particularly involves the removal or loss of calcium.	Osteolyses
D011095	Polyethylenes	Synthetic thermoplastics that are tough, flexible, inert, and resistant to chemicals and electrical current. They are often used as biocompatible materials for prostheses and implants.	Ethylene Polymers,Ethene Homopolymers,Homopolymers, Ethene,Polymers, Ethylene
D011475	Prosthesis Failure	Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.	Prosthesis Loosening,Prosthesis Durability,Prosthesis Migration,Prosthesis Survival,Durabilities, Prosthesis,Durability, Prosthesis,Failure, Prosthesis,Failures, Prosthesis,Loosening, Prosthesis,Loosenings, Prosthesis,Migration, Prosthesis,Migrations, Prosthesis,Prosthesis Durabilities,Prosthesis Failures,Prosthesis Loosenings,Prosthesis Migrations,Prosthesis Survivals,Survival, Prosthesis,Survivals, Prosthesis
D001843	Bone Cements	Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.	Bone Cement,Bone Glues,Bone Pastes,Bone Glue,Bone Paste,Cement, Bone,Cements, Bone,Glue, Bone,Glues, Bone,Paste, Bone,Pastes, Bone
D002857	Chromium	A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.
D003035	Cobalt	A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.	Cobalt-59,Cobalt 59
D005269	Femur	The longest and largest bone of the skeleton, it is situated between the hip and the knee.	Trochanter,Greater Trochanter,Lesser Trochanter,Femurs,Greater Trochanters,Lesser Trochanters,Trochanter, Greater,Trochanter, Lesser,Trochanters,Trochanters, Greater,Trochanters, Lesser