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Using the euglycaemic insulin-clamp technique we examined the effects of one-month metformin treatment on peripheral glucose utilization in non diabetic obese subjects. Two groups of obese subjects were studied in comparison with untreated lean women. Group 1 (n = 6) experienced weight loss (BMI: 32.6 +/- 1.7 vs 34.8 +/- 1.6 kg/m2, p < 0.05) but not group 2 (n = 7; BMI before and after treatment: 34.6 +/- 3.2 and 34.8 +/- 3.1 kg/m2). After a continuous insulin infusion of 40, 100, and 350 mU/m2/min we estimated the tissue sensitivity to insulin by the determination of Km, the glucose disposal (M), and the amount of glucose metabolized per U insulin (M/I ratio). After the metformin treatment the mean Km decreased by 31% in group 1 (p < 0.05) but not significantly in group 2; M and M/I were not modified in the two study groups. In conclusion, in non diabetic obese subjects, metformin seems not to affect peripheral insulin-mediated glucose metabolism unless there is weight loss.
S Fendri, and
X Debussche, and
H Puy, and
O Vincent, and
J M Marcelli, and
A Dubreuil, and
J D Lalau
January 2003,
Diabetes, nutrition & metabolism,
S Fendri, and
X Debussche, and
H Puy, and
O Vincent, and
J M Marcelli, and
A Dubreuil, and
J D Lalau
August 1986,
Diabete & metabolisme,
S Fendri, and
X Debussche, and
H Puy, and
O Vincent, and
J M Marcelli, and
A Dubreuil, and
J D Lalau
February 1996,
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity,
S Fendri, and
X Debussche, and
H Puy, and
O Vincent, and
J M Marcelli, and
A Dubreuil, and
J D Lalau
December 1986,
Diabete & metabolisme,
S Fendri, and
X Debussche, and
H Puy, and
O Vincent, and
J M Marcelli, and
A Dubreuil, and
J D Lalau
November 2012,
BMC endocrine disorders,
S Fendri, and
X Debussche, and
H Puy, and
O Vincent, and
J M Marcelli, and
A Dubreuil, and
J D Lalau
March 2003,
Atherosclerosis,
S Fendri, and
X Debussche, and
H Puy, and
O Vincent, and
J M Marcelli, and
A Dubreuil, and
J D Lalau
October 1983,
The Journal of clinical endocrinology and metabolism,
S Fendri, and
X Debussche, and
H Puy, and
O Vincent, and
J M Marcelli, and
A Dubreuil, and
J D Lalau
December 1980,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
S Fendri, and
X Debussche, and
H Puy, and
O Vincent, and
J M Marcelli, and
A Dubreuil, and
J D Lalau
June 2012,
Arthritis research & therapy,
S Fendri, and
X Debussche, and
H Puy, and
O Vincent, and
J M Marcelli, and
A Dubreuil, and
J D Lalau
April 2001,
Metabolism: clinical and experimental,
