BIOMAT Database Logo BIOMAT Database Logo

Studies of the effects of hypothermia on regional myocardial blood flow and metabolism during cardiopulmonary bypass. V. Profound topical hypothermia during ischemia in arrested hearts. 1977

R L Nelson, and S M Goldstein, and D H McConnell, and J V Maloney, and G D Buckberg

This study compares the effects of 60 minutes of ischemic arrest with profound topical hypothermia (10 dogs) on myocardial (1) blood flow and distribution (microspheres), (2) metabolism (oxygen and lactate), (3) water content (wet to dry weights), (4) compliance (intraventricular balloon), and (5) performance (isovolumetric function curves) with 180 minutes of cardiopulmonary bypass with the heart in the beating empty state (seven dogs). Studies performed before and 30 minutes after 1 hour of ischemic arrest with profound topical hypothermia showed: (1) total left ventricular blood flow increased 50 per cent but became redistributed away from the subendocardium (endocardial/epicardial flow ratio fell from 1.13 to 0.77,(2) left ventricular oxygen consumption fell 30 per cent while left ventricular oxygen extraction fell from 51 to 29 per cent; (3) lactate extraction fell from 15 to 4 per cent (two dogs produced lactate); (4) left ventricular endocardial (papillary muscle) water content rose 2.4 per cent; (5) left ventricular compliance decreased from 1.68 to 1.01 ml. H2O/mm. Hg (at 25 ml.); (6) left ventricular performance was depressed 49 per cent below control values. In contrast, 3 hours of cardiopulmonary bypass in the beating empty heart produced only minimal changes in these variables.

UI MeSH Term Description Entries
D007036 Hypothermia, Induced Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries. Induced Hypothermia,Mild Hypothermia, Induced,Moderate Hypothermia, Induced,Targeted Temperature Management,Therapeutic Hypothermia,Hypothermia, Therapeutic,Induced Mild Hypothermia,Induced Mild Hypothermias,Induced Moderate Hypothermia,Induced Moderate Hypothermias,Mild Hypothermias, Induced,Moderate Hypothermias, Induced,Targeted Temperature Managements
D007511 Ischemia A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION. Ischemias
D007773 Lactates Salts or esters of LACTIC ACID containing the general formula CH3CHOHCOOR.
D008863 Microspheres Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers. Latex Beads,Latex Particles,Latex Spheres,Microbeads,Bead, Latex,Beads, Latex,Latex Bead,Latex Particle,Latex Sphere,Microbead,Microsphere,Particle, Latex,Particles, Latex,Sphere, Latex,Spheres, Latex
D009200 Myocardial Contraction Contractile activity of the MYOCARDIUM. Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D009206 Myocardium The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow. Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D010101 Oxygen Consumption The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346) Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D001831 Body Temperature The measure of the level of heat of a human or animal. Organ Temperature,Body Temperatures,Organ Temperatures,Temperature, Body,Temperature, Organ,Temperatures, Body,Temperatures, Organ
D001834 Body Water Fluids composed mainly of water found within the body. Water, Body
D002315 Cardiopulmonary Bypass Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs. Heart-Lung Bypass,Bypass, Cardiopulmonary,Bypass, Heart-Lung,Bypasses, Cardiopulmonary,Bypasses, Heart-Lung,Cardiopulmonary Bypasses,Heart Lung Bypass,Heart-Lung Bypasses

Related Publications

R L Nelson, and S M Goldstein, and D H McConnell, and J V Maloney, and G D Buckberg
Studies of the effects of hypothermia on regional myocardial blood flow and metabolism during cardiopulmonary bypass. IV. Topical atrial hypothermia in normothermic beating hearts.
February 1977, The Journal of thoracic and cardiovascular surgery,
R L Nelson, and S M Goldstein, and D H McConnell, and J V Maloney, and G D Buckberg
Studies of the effects of hypothermia on regional myocardial blood flow and metabolsim during cardiopulmonary bypass. II. Ischemia during moderate hypothermia in continually perfused beating hearts.
January 1977, The Journal of thoracic and cardiovascular surgery,
R L Nelson, and S M Goldstein, and D H McConnell, and J V Maloney, and G D Buckberg
Studies of the effects of hypothermia on regional myocardial blood flow and metabolism during cardiopulmonary bypass. III. Effects of temperature, time, and perfusion pressure in fibrillating hearts.
January 1977, The Journal of thoracic and cardiovascular surgery,
R L Nelson, and S M Goldstein, and D H McConnell, and J V Maloney, and G D Buckberg
Comparison of catecholamine effects on canine myocardial metabolism and regional blood flow during and after cardiopulmonary bypass.
March 1984, The Journal of thoracic and cardiovascular surgery,
R L Nelson, and S M Goldstein, and D H McConnell, and J V Maloney, and G D Buckberg
Effects of temperature and flow rate on regional blood flow and metabolism during cardiopulmonary bypass.
June 1992, The Annals of thoracic surgery,
R L Nelson, and S M Goldstein, and D H McConnell, and J V Maloney, and G D Buckberg
Carbohydrate metabolism during pulsatile cardiopulmonary bypass under profound hypothermia.
May 1983, Japanese circulation journal,
R L Nelson, and S M Goldstein, and D H McConnell, and J V Maloney, and G D Buckberg
Effects of methylprednisolone on coronary blood flow and myocardial metabolism during cardiopulmonary bypass.
June 1977, Surgery,
R L Nelson, and S M Goldstein, and D H McConnell, and J V Maloney, and G D Buckberg
[Application of pulsatile cardiopulmonary bypass for profound hypothermia in cardiac surgery--studies on carbohydrate metabolism].
September 1982, [Zasshi] [Journal]. Nihon Kyobu Geka Gakkai,
R L Nelson, and S M Goldstein, and D H McConnell, and J V Maloney, and G D Buckberg
[The effects of left ventricular distention on coronary blood flow and myocardial metabolism during cardiopulmonary bypass (author's transl)].
June 1975, Thoraxchirurgie, vaskulare Chirurgie,
R L Nelson, and S M Goldstein, and D H McConnell, and J V Maloney, and G D Buckberg
Cerebral blood flow and metabolism during cardiopulmonary bypass.
April 1993, Anesthesia and analgesia,
Copied contents to your clipboard!