BIOMAT Database Logo BIOMAT Database Logo

Prostaglandin influence on pulmonary intravascular leukocytic aggregation during cardiopulmonary bypass. 1977

P J Bolanowski, and J Bauer, and G Machiedo, and W E Neville

A variety of pharmacologic agents have been infused during cardiopulmonary bypass in an attempt to prevent intravascular leukocytic aggregation in the lung. To date corticosteroids have been advocated because of their ability to stabilize lysosomes. We have studied two additional agents, prostaglandin E1 (PGE1) and dipyramidole (DIPYR) and compared their effects with those of methylprednisolone sodium succinate (MPSS) and a control group. The drugs were infused into the dog during perfusion and lung biopsies obtained before, during, and at the end of 2 hours of cardiopulmonary bypass using whole blood prime of the Bentley bubble oxygenator. The biopsies were interpreted by a pathologist who was unaware of the modality of treatment. Our results indicate that PGE1 provides more protection from intravascular pulmonary leukocytic aggregation than DIPYR and MPSS.

UI MeSH Term Description Entries
D007962 Leukocytes White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES). Blood Cells, White,Blood Corpuscles, White,White Blood Cells,White Blood Corpuscles,Blood Cell, White,Blood Corpuscle, White,Corpuscle, White Blood,Corpuscles, White Blood,Leukocyte,White Blood Cell,White Blood Corpuscle
D008171 Lung Diseases Pathological processes involving any part of the LUNG. Pulmonary Diseases,Disease, Pulmonary,Diseases, Pulmonary,Pulmonary Disease,Disease, Lung,Diseases, Lung,Lung Disease
D008775 Methylprednisolone A PREDNISOLONE derivative with similar anti-inflammatory action. 6-Methylprednisolone,Medrol,Metipred,Urbason,6 Methylprednisolone
D011458 Prostaglandins E (11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities. PGE
D011652 Pulmonary Circulation The circulation of the BLOOD through the LUNGS. Pulmonary Blood Flow,Respiratory Circulation,Circulation, Pulmonary,Circulation, Respiratory,Blood Flow, Pulmonary,Flow, Pulmonary Blood,Pulmonary Blood Flows
D002315 Cardiopulmonary Bypass Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs. Heart-Lung Bypass,Bypass, Cardiopulmonary,Bypass, Heart-Lung,Bypasses, Cardiopulmonary,Bypasses, Heart-Lung,Cardiopulmonary Bypasses,Heart Lung Bypass,Heart-Lung Bypasses
D002449 Cell Aggregation The phenomenon by which dissociated cells intermixed in vitro tend to group themselves with cells of their own type. Aggregation, Cell,Aggregations, Cell,Cell Aggregations
D004176 Dipyridamole A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) Antistenocardin,Apo-Dipyridamole,Cerebrovase,Cléridium,Curantil,Curantyl,Dipyramidole,Kurantil,Miosen,Novo-Dipiradol,Persantin,Persantine,Apo Dipyridamole,Novo Dipiradol
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog

Related Publications

P J Bolanowski, and J Bauer, and G Machiedo, and W E Neville
Prostaglandin E biosynthesis during cardiopulmonary bypass.
March 1978, The Journal of surgical research,
P J Bolanowski, and J Bauer, and G Machiedo, and W E Neville
Platelet activation and aggregation during cardiopulmonary bypass.
September 1991, Anesthesiology,
P J Bolanowski, and J Bauer, and G Machiedo, and W E Neville
Accelerated Intravascular Activation of Coagulation During Cardiopulmonary Bypass.
July 2020, Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion,
P J Bolanowski, and J Bauer, and G Machiedo, and W E Neville
Increased anticoagulation during cardiopulmonary bypass by prostaglandin E1.
November 1998, Anesthesia and analgesia,
P J Bolanowski, and J Bauer, and G Machiedo, and W E Neville
[Effects of prostaglandin E1 infusion during cardiopulmonary bypass].
August 1989, Masui. The Japanese journal of anesthesiology,
P J Bolanowski, and J Bauer, and G Machiedo, and W E Neville
Platelet activation and aggregation during normothermic cardiopulmonary bypass.
September 2001, The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi,
P J Bolanowski, and J Bauer, and G Machiedo, and W E Neville
Platelet activation and aggregation during normothermic cardiopulmonary bypass.
January 2001, The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi,
P J Bolanowski, and J Bauer, and G Machiedo, and W E Neville
Pulmonary artery rupture during cardiopulmonary bypass.
February 1987, Journal of cardiothoracic anesthesia,
P J Bolanowski, and J Bauer, and G Machiedo, and W E Neville
Pulmonary artery rupture during cardiopulmonary bypass.
October 1987, Journal of cardiothoracic anesthesia,
P J Bolanowski, and J Bauer, and G Machiedo, and W E Neville
Prostaglandin synthesis inhibitor improves hypotension during normothermic cardiopulmonary bypass.
January 2001, ASAIO journal (American Society for Artificial Internal Organs : 1992),
Copied contents to your clipboard!