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Coeliac disease is strongly associated with HLA-DQ2, but it is possible that additional major histocompatibility complex genes also confer disease susceptibility. Encoded close to HLA-DQ are two genes, TAP1 and TAP2, whose products are believed to transport antigenic peptides from the cytoplasm into the endoplasmic reticulum. Comparison of 81 coeliac disease patients with caucasoid controls revealed an increased frequency of the alleles TAP1A and TAP2A in the patient population. However, no significant difference was found when patients were compared with HLA-DR and -DQ matched controls, indicating linkage disequilibrium between TAP1A, TAP2A, and HLA-DQ2. The TAP gene products do not have a major influence on susceptibility or resistance to coeliac disease in a Northern European Caucasoid population.
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J S Lanchbury, and
J I Bell
January 2000,
Experimental and clinical immunogenetics,
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W M Rosenberg, and
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Tissue antigens,
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W M Rosenberg, and
M Hall, and
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January 1997,
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Pediatric pulmonology,
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Methods in molecular biology (Clifton, N.J.),
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June 2002,
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics,
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Cellular & molecular immunology,
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