-transparent.png){kind=logo}
Correlation of tri-ortho-cresyl phosphate (TOCP) toxicity with clinical symptoms and inhibition patterns of neurotoxic esterase (NTE) in different regions of the central nervous system was studied in hens. The total content of NTE in spinal cord and peripheral nerves was relatively much lower than that of the brain, about 29 and 4.8 per cent respectively. Brain and spinal cord NTE was inhibited to 75 and 67 per cent respectively on day 1 post-TOCP treatment, and 91 and 84 per cent respectively on day 2, while the activity of the enzyme in peripheral nerve was inhibited to 92 per cent on day 1. However, the clinical manifestations of paralysis appeared after 7-8 days of TOCP treatment. It can be concluded that the presence of NTE in very low quantities in the peripheral nerves and its almost complete inhibition as compared to that of brain and spinal cord, could be of great significance in the development of neurotoxicity.
S Biswas, and
S K Biswas, and
A K Bhattacharyya
December 1952,
British journal of pharmacology and chemotherapy,
S Biswas, and
S K Biswas, and
A K Bhattacharyya
January 1973,
Acta histochemica,
S Biswas, and
S K Biswas, and
A K Bhattacharyya
October 1953,
Nature,
S Biswas, and
S K Biswas, and
A K Bhattacharyya
May 2007,
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases,
S Biswas, and
S K Biswas, and
A K Bhattacharyya
December 1966,
Ceskoslovenska gastroenterologie a vyziva,
S Biswas, and
S K Biswas, and
A K Bhattacharyya
September 2004,
Toxicology letters,
S Biswas, and
S K Biswas, and
A K Bhattacharyya
June 1952,
British journal of pharmacology and chemotherapy,
S Biswas, and
S K Biswas, and
A K Bhattacharyya
February 1966,
Experimental neurology,
S Biswas, and
S K Biswas, and
A K Bhattacharyya
February 1953,
The Biochemical journal,
S Biswas, and
S K Biswas, and
A K Bhattacharyya
June 1963,
Kiserletes orvostudomany,
