Biomaterial Database

Dupuytren's disease in identical twins. 1993

H A Lyall

Department of Orthopaedic and Trauma Surgery, Addenbrooke's Hospital, Cambridge, UK.

The aetiology of Dupuytren's disease remains unknown, although hereditary and environmental influences have been implicated. Previous reports have suggested that identical twins will develop identical contractures. This paper reports two pairs of identical twins, in each of which only one twin has evidence of Dupuytren's disease. This demonstrates that an appropriate genetic background is inadequate of itself for the development of Dupuytren's disease without a suitable, and as yet unknown, environmental trigger.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D004200	Diseases in Twins	Disorders affecting TWINS, one or both, at any age.	Diseases in Twin,Twin, Diseases in,Twins, Diseases in,in Twin, Diseases,in Twins, Diseases
D004387	Dupuytren Contracture	A fibromatosis of the palmar fascia characterized by thickening and contracture of the fibrous bands on the palmar surfaces of the hand and fingers. It arises most commonly in men between the ages of 30 and 50.	Dupuytren's Contracture,Dupuytren's Disease,Fibromatosis, Palmar,Contracture, Dupuytren,Contracture, Dupuytren's,Dupuytren Disease,Dupuytrens Contracture,Dupuytrens Disease,Palmar Fibromatosis
D005385	Fingers	Four or five slender jointed digits in humans and primates, attached to each HAND.	Finger
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D014430	Twins, Monozygotic	Two off-spring from the same PREGNANCY. They are from a single fertilized OVUM that split into two EMBRYOS. Such twins are usually genetically identical and of the same sex.	Twins, Identical,Identical Twin,Identical Twins,Monozygotic Twin,Monozygotic Twins,Twin, Identical,Twin, Monozygotic