We describe herein a renal transplant recipient who developed cutaneous squamous cell carcinoma 15 years after the first transplantation. A 41-year-old Japanese man received a renal transplant from his mother for end-stage glomerulonephritis in December 1975 when he was 25 years old. Unfortunately, he suffered irreversible chronic rejection and returned to hemodialysis in March 1986. In December 1986 he received the second renal transplant from his father. In November 1990, the patient developed a nodule just lateral to his right lateral eye angle. He was treated with cryosurgery by a nearby dermatologist four times. However, the lesion did not improve, and he came to our hospital. Cutaneous biopsy specimen showed squamous cell carcinoma. The nodule was resected without decreasing the dose of cyclosporine and azathioprine. He has remained asymptomatic with out evidence of recurrent cutaneous lesions for two years of followup. This patient seems to represent the 3rd case of cutaneous cancer after renal transplantation in Japan.