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We previously reported that the racemic mixture and both enantiomers of gossypol inhibit the replication of human immunodeficiency virus-type 1 (HIV-1) (Lin et al., Antimicrob Agents Chemother 33: 2149-2151, 1989). The present study evaluates the activities of a variety of analogs of gossypol as well as a few non-gossypol analogs. Compounds 2, 3, 10, and 13 were slightly more inhibitory than (-)-gossypol to the replication of HIV-1 in cell culture. Compounds 4 and 8 were cytotoxic to human peripheral blood monocyte (PBM) cells, and compounds 2 and 3 were cytotoxic to Vero cells but not PBM cells. The effects of the two enantiomers of gossypol on the cell volume and migration of H9 cells through the cell cycle were evaluated during 72 hr of incubation. The (-)-enantiomer of gossypol was more toxic to H9 cells than the (+)-enantiomer of gossypol as evidenced by cell destruction. Prior to cell destruction, there appeared to be no significant effect on cell cycle distribution with either enantiomer.
T S Lin, and
R F Schinazi, and
J Zhu, and
E Birks, and
R Carbone, and
Y Si, and
K Wu, and
L Huang, and
W H Prusoff
September 1990,
AIDS research and human retroviruses,
T S Lin, and
R F Schinazi, and
J Zhu, and
E Birks, and
R Carbone, and
Y Si, and
K Wu, and
L Huang, and
W H Prusoff
March 2013,
Antimicrobial agents and chemotherapy,
T S Lin, and
R F Schinazi, and
J Zhu, and
E Birks, and
R Carbone, and
Y Si, and
K Wu, and
L Huang, and
W H Prusoff
January 2011,
Yao xue xue bao = Acta pharmaceutica Sinica,
T S Lin, and
R F Schinazi, and
J Zhu, and
E Birks, and
R Carbone, and
Y Si, and
K Wu, and
L Huang, and
W H Prusoff
October 1999,
Advanced drug delivery reviews,
T S Lin, and
R F Schinazi, and
J Zhu, and
E Birks, and
R Carbone, and
Y Si, and
K Wu, and
L Huang, and
W H Prusoff
June 2010,
Letters in drug design & discovery,
T S Lin, and
R F Schinazi, and
J Zhu, and
E Birks, and
R Carbone, and
Y Si, and
K Wu, and
L Huang, and
W H Prusoff
May 2008,
Current opinion in HIV and AIDS,
T S Lin, and
R F Schinazi, and
J Zhu, and
E Birks, and
R Carbone, and
Y Si, and
K Wu, and
L Huang, and
W H Prusoff
September 2002,
Biochemical and biophysical research communications,
T S Lin, and
R F Schinazi, and
J Zhu, and
E Birks, and
R Carbone, and
Y Si, and
K Wu, and
L Huang, and
W H Prusoff
October 1992,
Annals of the New York Academy of Sciences,
T S Lin, and
R F Schinazi, and
J Zhu, and
E Birks, and
R Carbone, and
Y Si, and
K Wu, and
L Huang, and
W H Prusoff
October 2019,
International journal of molecular sciences,
T S Lin, and
R F Schinazi, and
J Zhu, and
E Birks, and
R Carbone, and
Y Si, and
K Wu, and
L Huang, and
W H Prusoff
August 2009,
Chemical biology & drug design,
