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Cerebrospinal fluid (CSF) neopterin levels were determined by high-pressure liquid chromatography in 48 normal children and in 15 children with meningeal relapse of hematologic malignancies (13 acute lymphoblastic leukemia and 2 high-grade lymphomas). When meningeal relapse was diagnosed, all patients had CSF neopterin levels higher than mean normal value +2 standard deviations. No significant correlation between the blast count in the CSF and neopterin levels was observed. CSF data before relapse were available in 10 children: the neopterin values at relapse were significantly higher than values observed at diagnosis. In 3 patients, elevated neopterin levels preceded the occurrence of neurologic signs and the detection of blast cells in CSF by 15 to 30 days. In the absence of infection, the rise of CSF neopterin levels in patients with hematologic malignancies indicates an active phase of the disease. This could reflect a cell-mediated immunologic process induced by malignant cells. The measurement of CSF neopterin should be helpful in the monitoring of patients to detect early meningeal relapse.
F Millot, and
J L Dhondt, and
F Mazingue, and
F Mechinaud, and
J L Auget, and
F Bauters, and
J L Harousseau
November 1993,
The Journal of infectious diseases,
F Millot, and
J L Dhondt, and
F Mazingue, and
F Mechinaud, and
J L Auget, and
F Bauters, and
J L Harousseau
April 1989,
Zhonghua yi xue za zhi = Chinese medical journal; Free China ed,
F Millot, and
J L Dhondt, and
F Mazingue, and
F Mechinaud, and
J L Auget, and
F Bauters, and
J L Harousseau
April 2003,
Brain & development,
F Millot, and
J L Dhondt, and
F Mazingue, and
F Mechinaud, and
J L Auget, and
F Bauters, and
J L Harousseau
March 1977,
Clinica chimica acta; international journal of clinical chemistry,
F Millot, and
J L Dhondt, and
F Mazingue, and
F Mechinaud, and
J L Auget, and
F Bauters, and
J L Harousseau
March 1987,
Acta paediatrica Scandinavica,
F Millot, and
J L Dhondt, and
F Mazingue, and
F Mechinaud, and
J L Auget, and
F Bauters, and
J L Harousseau
January 1991,
Leukemia research,
F Millot, and
J L Dhondt, and
F Mazingue, and
F Mechinaud, and
J L Auget, and
F Bauters, and
J L Harousseau
July 1996,
No to hattatsu = Brain and development,
F Millot, and
J L Dhondt, and
F Mazingue, and
F Mechinaud, and
J L Auget, and
F Bauters, and
J L Harousseau
April 2009,
Developmental medicine and child neurology,
F Millot, and
J L Dhondt, and
F Mazingue, and
F Mechinaud, and
J L Auget, and
F Bauters, and
J L Harousseau
November 2018,
Journal of neuroinflammation,
F Millot, and
J L Dhondt, and
F Mazingue, and
F Mechinaud, and
J L Auget, and
F Bauters, and
J L Harousseau
December 1987,
Leukemia,
