BIOMAT Database Logo BIOMAT Database Logo

Sleep-inducing function of noradrenergic fibers in the medial preoptic area. 1993

V M Kumar, and R Sharma, and S Wadhwa, and S K Manchanda
Department of Physiology and Anatomy, All India Institute of Medical Sciences, New Delhi.

The aim of the investigation was to find out the role of noradrenergic (NE) terminals of the medial preoptic area (mPOA), in the regulation of sleep-wakefulness. Studies were conducted on free-moving adult male rats with chronically implanted cannulae in the mPOA. Sleep-wakefulness was assessed on the basis of EEG, EMG, and EOG recordings along with behavioral observations. Lesioning of catecholamine terminals (with 6-hydroxydopamine) in the mPOA produced an increase in quiet wakefulness. Prevention of NE fiber destruction, by pretreating the rats with imipramine, prevented this effect. This demonstrated that the increased quiet wakefulness produced by 6-OHDA was the result of NE fiber destruction. Changes in sleep-wakefulness were also assessed after microinjection of NE into the mPOA, in normal and ventral noradrenergic bundle (VNA)-lesioned rats. NE administration induced sleep in VNA-lesioned rats, and arousal in normal rats. The findings suggest that the NE terminals in the mPOA, projecting via VNA, play a role in the induction of sleep.

UI MeSH Term Description Entries
D008297 Male Males
D009412 Nerve Fibers Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM. Cerebellar Mossy Fibers,Mossy Fibers, Cerebellar,Cerebellar Mossy Fiber,Mossy Fiber, Cerebellar,Nerve Fiber
D009638 Norepinephrine Precursor of epinephrine that is secreted by the ADRENAL MEDULLA and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the LOCUS CERULEUS. It is also found in plants and is used pharmacologically as a sympathomimetic. Levarterenol,Levonorepinephrine,Noradrenaline,Arterenol,Levonor,Levophed,Levophed Bitartrate,Noradrenaline Bitartrate,Noradrénaline tartrate renaudin,Norepinephrin d-Tartrate (1:1),Norepinephrine Bitartrate,Norepinephrine Hydrochloride,Norepinephrine Hydrochloride, (+)-Isomer,Norepinephrine Hydrochloride, (+,-)-Isomer,Norepinephrine d-Tartrate (1:1),Norepinephrine l-Tartrate (1:1),Norepinephrine l-Tartrate (1:1), (+,-)-Isomer,Norepinephrine l-Tartrate (1:1), Monohydrate,Norepinephrine l-Tartrate (1:1), Monohydrate, (+)-Isomer,Norepinephrine l-Tartrate (1:2),Norepinephrine l-Tartrate, (+)-Isomer,Norepinephrine, (+)-Isomer,Norepinephrine, (+,-)-Isomer
D011301 Preoptic Area Region of hypothalamus between the ANTERIOR COMMISSURE and OPTIC CHIASM. Area Preoptica,Lateral Preoptic Area,Medial Preoptic Area,Preoptic Nuclei,Area Preopticas,Area, Lateral Preoptic,Area, Medial Preoptic,Area, Preoptic,Areas, Lateral Preoptic,Areas, Medial Preoptic,Areas, Preoptic,Lateral Preoptic Areas,Medial Preoptic Areas,Nuclei, Preoptic,Nucleus, Preoptic,Preoptic Area, Lateral,Preoptic Area, Medial,Preoptic Areas,Preoptic Areas, Lateral,Preoptic Areas, Medial,Preoptic Nucleus,Preoptica, Area,Preopticas, Area
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012890 Sleep A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility. Sleep Habits,Sleeping Habit,Sleeping Habits,Habit, Sleep,Habit, Sleeping,Habits, Sleep,Habits, Sleeping,Sleep Habit
D014851 Wakefulness A state in which there is an enhanced potential for sensitivity and an efficient responsiveness to external stimuli. Wakefulnesses
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

V M Kumar, and R Sharma, and S Wadhwa, and S K Manchanda
Role of noradrenergic fibers of the preoptic area in regulating sleep.
October 2003, Journal of chemical neuroanatomy,
V M Kumar, and R Sharma, and S Wadhwa, and S K Manchanda
A1 noradrenergic input to medial preoptic-medial septal area: an electrophysiological study.
January 1987, Neuroendocrinology,
V M Kumar, and R Sharma, and S Wadhwa, and S K Manchanda
Sleep-inducing effects of adenosine microinjections into the medial preoptic area are blocked by flumazenil.
January 2000, Brain research,
V M Kumar, and R Sharma, and S Wadhwa, and S K Manchanda
Sleep inducing effects of propofol microinjection into the medial preoptic area are blocked by flumazenil.
July 2001, Brain research,
V M Kumar, and R Sharma, and S Wadhwa, and S K Manchanda
The sleep-inducing effect of ethanol microinjection into the medial preoptic area is blocked by flumazenil.
February 2001, Brain research,
V M Kumar, and R Sharma, and S Wadhwa, and S K Manchanda
Recovery of sleep after fetal preoptic transplantation in medial preoptic area-lesioned rats.
September 1998, Sleep,
V M Kumar, and R Sharma, and S Wadhwa, and S K Manchanda
Why the medial preoptic area is important for sleep regulation.
April 2004, Indian journal of physiology and pharmacology,
V M Kumar, and R Sharma, and S Wadhwa, and S K Manchanda
Noradrenergic afferents and receptors in the medial preoptic area: neuroanatomical and neurochemical links between the regulation of sleep and body temperature.
May 2007, Neurochemistry international,
V M Kumar, and R Sharma, and S Wadhwa, and S K Manchanda
Functional MRI shows activation of the medial preoptic area during sleep.
May 2005, NeuroImage,
V M Kumar, and R Sharma, and S Wadhwa, and S K Manchanda
Melatonin microinjection into the medial preoptic area increases sleep in the rat.
September 2002, Life sciences,
Copied contents to your clipboard!