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Mitomycin-C plus a 3-day continuous intravenous infusion of 5-fluorouracil: an inactive salvage regimen for platinum-resistant ovarian carcinoma. 1993
B Reichman, and
M Markman, and
T Hakes, and
S Rubin, and
W Jones, and
J Curtin, and
R Barakat, and
L Almadrones, and
J L Lewis, and
W Hoskins
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
In a Phase II trial, patients with refractory ovarian cancer were given 10 mg/m2 mitomycin-C i.v. every 8 weeks and 1000 mg/m2/day 5-fluorouracil for 3 consecutive days by continuous intravenous infusion repeated every 4 weeks. Sixteen heavily pretreated patients with platinum-resistant disease were treated and no major responses were observed. Only 2 patients required subsequent dose reduction for myelotoxicity. No sign of gastrointestinal toxicity was seen. This regimen is inactive as salvage treatment for refractory ovarian cancer.
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