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The organophosphate insecticide quinalphos is extensively used in agriculture. Information on the mammalian toxicity of quinalphos is limited. The acute po LD50 of technical quinalphos was 19.95 mg/kg in males and 13.78 mg/kg in female rats. Administration of 0.75, 1.50 or 3.0 mg/kg/d technical quinalphos for 90 d po to rats produced poisoning and death. Male rats were more susceptible to quinalphos than female rats in the subchronic toxicity studies based on mortality, enzyme profiles and cholinesterase inhibition.
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