BIOMAT Database Logo BIOMAT Database Logo

Axonal neurofilamentous accumulations: a comparison between human and canine giant axonal neuropathy and 2,5-HD neuropathy. 1993

R H King, and M Sarsilmaz, and P K Thomas, and J M Jacobs, and J R Muddle, and I D Duncan
Royal Free Hospital School of Medicine, London.

The neuropathy produced by the hexacarbon 2,5-hexanedione (2,5-HD) resembles human and canine inherited giant axonal neuropathy (GAN) in the presence of giant axonal swellings that contain accumulations of neurofilaments. The accumulations are both paranodal and internodal in GAN and 2,5-HD induced neuropathy. Detailed morphometry on the neurofilaments reveals that the changes in human and canine GAN are closely similar and differ from those of 2,5-HD neuropathy, suggesting that the mechanisms underlying the formation of the axonal neurofilamentous accumulations differ between the two conditions. In both human and canine GAN, the neurofilaments are more closely spaced and are of greater diameter than in 2,5-HD neuropathy. The changes in the NF in GAN may be the consequence of flattening of the side-arms of the neurofilaments against the axis of the filaments.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D007382 Intermediate Filaments Cytoplasmic filaments intermediate in diameter (about 10 nanometers) between the microfilaments and the microtubules. They may be composed of any of a number of different proteins and form a ring around the cell nucleus. Tonofilaments,Neurofilaments,Filament, Intermediate,Filaments, Intermediate,Intermediate Filament,Neurofilament,Tonofilament
D008297 Male Males
D008854 Microscopy, Electron Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen. Electron Microscopy
D009422 Nervous System Diseases Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle. Neurologic Disorders,Nervous System Disorders,Neurological Disorders,Disease, Nervous System,Diseases, Nervous System,Disorder, Nervous System,Disorder, Neurologic,Disorder, Neurological,Disorders, Nervous System,Disorders, Neurologic,Disorders, Neurological,Nervous System Disease,Nervous System Disorder,Neurologic Disorder,Neurological Disorder
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D006588 Hexanones 6-carbon straight-chain or branched ketones. Butyl Methyl Ketones,Ethyl Propyl Ketones,Ketones, Butyl Methyl,Ketones, Ethyl Propyl,Methyl Ketones, Butyl,Propyl Ketones, Ethyl
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

R H King, and M Sarsilmaz, and P K Thomas, and J M Jacobs, and J R Muddle, and I D Duncan
Giant axonal neuropathy--a unique case with segmental neurofilamentous masses.
January 1972, Acta neuropathologica,
R H King, and M Sarsilmaz, and P K Thomas, and J M Jacobs, and J R Muddle, and I D Duncan
Canine giant axonal neuropathy.
November 1977, The Veterinary record,
R H King, and M Sarsilmaz, and P K Thomas, and J M Jacobs, and J R Muddle, and I D Duncan
"Giant axonal neuropathy" caused by industrial chemicals: neurofilamentous axonal masses in man.
October 1976, Neurology,
R H King, and M Sarsilmaz, and P K Thomas, and J M Jacobs, and J R Muddle, and I D Duncan
Inherited canine giant axonal neuropathy.
January 1981, Muscle & nerve,
R H King, and M Sarsilmaz, and P K Thomas, and J M Jacobs, and J R Muddle, and I D Duncan
The central nervous system in canine giant axonal neuropathy.
May 1979, Acta neuropathologica,
R H King, and M Sarsilmaz, and P K Thomas, and J M Jacobs, and J R Muddle, and I D Duncan
Peripheral nervous system in a case of canine giant axonal neuropathy.
January 1979, Neuropathology and applied neurobiology,
R H King, and M Sarsilmaz, and P K Thomas, and J M Jacobs, and J R Muddle, and I D Duncan
Giant axonal neuropathy.
October 1993, Neurology,
R H King, and M Sarsilmaz, and P K Thomas, and J M Jacobs, and J R Muddle, and I D Duncan
Giant axonal neuropathy.
October 2004, Developmental medicine and child neurology,
R H King, and M Sarsilmaz, and P K Thomas, and J M Jacobs, and J R Muddle, and I D Duncan
Giant axonal neuropathy.
June 2015, Journal of child neurology,
R H King, and M Sarsilmaz, and P K Thomas, and J M Jacobs, and J R Muddle, and I D Duncan
[Neuropathy, giant axonal].
January 2001, Ryoikibetsu shokogun shirizu,
Copied contents to your clipboard!