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The effect of cholecystokinin on the myoelectric activity of the small intestine was determined in conscious dogs. Six animals were implanted with electrodes along the small intestine, and a cannula was placed in the stomach. A second cannula was inserted into the duodenum in three animals, and a pancreatic fistula was prepared in three animals. Recordings were made in the fasted state, during the intravenous infusion of either saline or cholecystokinin-octapeptide (CCK-OP), during the intraduodenal infusion of either saline or L-tryptophan, and during the fed state. CCK-OP disrupted the fasted pattern of myoelectric activity, caused a dose-dependent increase in spike potentials, and caused a dose-dependent increases in pancreatic protein secretion. Stimulation of myoelectric activity occurred at doses that produced submaximal protein secretion; however, the stimulation was not identical to that seen with feeding. Intraduodenal infusion of L-tryptophan increased pancreatic protein secretion, interrupted the fasted pattern of motility, and induced a pattern similar to that seen with feeding. We conclude that CCK alters small intestinal motility and may play a role in the changes in small-bowel motility caused by the ingestion of food.
A K Mukhopadhyay, and
P J Thor, and
E M Copeland, and
L R Johnson, and
N W Weisbrodt
January 2001,
Folia medica Cracoviensia,
A K Mukhopadhyay, and
P J Thor, and
E M Copeland, and
L R Johnson, and
N W Weisbrodt
June 1970,
The American journal of digestive diseases,
A K Mukhopadhyay, and
P J Thor, and
E M Copeland, and
L R Johnson, and
N W Weisbrodt
June 1993,
American journal of surgery,
A K Mukhopadhyay, and
P J Thor, and
E M Copeland, and
L R Johnson, and
N W Weisbrodt
December 1982,
The American journal of physiology,
A K Mukhopadhyay, and
P J Thor, and
E M Copeland, and
L R Johnson, and
N W Weisbrodt
June 1994,
Digestive diseases and sciences,
A K Mukhopadhyay, and
P J Thor, and
E M Copeland, and
L R Johnson, and
N W Weisbrodt
January 1989,
Acta physiologica Polonica,
A K Mukhopadhyay, and
P J Thor, and
E M Copeland, and
L R Johnson, and
N W Weisbrodt
January 1980,
The American journal of physiology,
A K Mukhopadhyay, and
P J Thor, and
E M Copeland, and
L R Johnson, and
N W Weisbrodt
March 1992,
The American journal of physiology,
A K Mukhopadhyay, and
P J Thor, and
E M Copeland, and
L R Johnson, and
N W Weisbrodt
January 1977,
American journal of surgery,
A K Mukhopadhyay, and
P J Thor, and
E M Copeland, and
L R Johnson, and
N W Weisbrodt
January 1980,
Digestive diseases and sciences,
