BIOMAT Database Logo BIOMAT Database Logo

Fibrosing cholestatic hepatitis in a transplant recipient with hepatitis B virus precore mutant. 1993

J W Fang, and F Y Tung, and G L Davis, and D J Dolson, and D H Van Thiel, and J Y Lau
Section of Hepatobiliary Diseases, University of Florida College of Medicine, Gainesville.

A patient with hepatitis B virus (HBV) precore mutant (seropositive for hepatitis B surface antigen [HBsAg], anti-hepatitis B e antigen [HBeAg], and HBV DNA) who underwent orthotopic liver transplantation for end-stage liver disease is described. Sequencing of the HBV precore region of the pretransplant serum sample confirmed the presence of the precore stop-codon mutant (G-->A mutation in codon 1896) only. The patient received HBV immunoglobulin prophylaxis for 6 months but HBV recurred thereafter with a mild hepatitic flare, and he remained seropositive for HBsAg, anti-HBe, and HBV DNA. The initial hepatitic illness resolved in 3 months. The patient remained well for another 16 months before presenting with fibrosing cholestatic hepatitis (FCH). During his entire initial hepatitic flare, quiescent period, and final FCH phase, he remained seropositive for HBsAg, anti-HBe, and HBV DNA. Moreover, sequencing of the serum HBV DNA in final FCH phase showed the presence of the identical HBV precore mutant. Immunohistochemical staining showed extensive expression of HBsAg/pre-S1, pre-S2, and hepatitis B core antigen, but HBeAg was scarcely detectable. This case illustrates that (1) recurrence of HBV precore mutant infection can occur in liver; (2) it can give rise to FCH; and (3) hepatic accumulation of HBeAg is not essential for the development of FCH.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008103 Liver Cirrhosis Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules. Cirrhosis, Liver,Fibrosis, Liver,Hepatic Cirrhosis,Liver Fibrosis,Cirrhosis, Hepatic
D008297 Male Males
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D002780 Cholestasis, Intrahepatic Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC). Bile Duct Obstruction, Intrahepatic,Biliary Stasis, Intrahepatic,Intrahepatic Cholestasis,Biliary Stases, Intrahepatic,Cholestases, Intrahepatic,Intrahepatic Biliary Stases,Intrahepatic Biliary Stasis,Intrahepatic Cholestases
D004279 DNA, Viral Deoxyribonucleic acid that makes up the genetic material of viruses. Viral DNA
D006509 Hepatitis B INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact. Hepatitis B Virus Infection
D006513 Hepatitis B e Antigens A closely related group of antigens found in the plasma only during the infective phase of hepatitis B or in virulent chronic hepatitis B, probably indicating active virus replication; there are three subtypes which may exist in a complex with immunoglobulins G. HBeAg,Hepatitis B e Antigen,Hepatitis Be Antigen,e Antigen,e Antigens,HBe Ag-1,HBe Ag-2,Hepatitis Be Antigens,Antigen, Hepatitis Be,Antigen, e,Antigens, Hepatitis Be,Antigens, e,Be Antigen, Hepatitis,Be Antigens, Hepatitis

Related Publications

J W Fang, and F Y Tung, and G L Davis, and D J Dolson, and D H Van Thiel, and J Y Lau
Fibrosing cholestatic hepatitis in a renal transplant recipient associated with the hepatitis B virus precore mutant.
April 1995, Journal of hepatology,
J W Fang, and F Y Tung, and G L Davis, and D J Dolson, and D H Van Thiel, and J Y Lau
Fibrosing cholestatic hepatitis in a kidney transplant recipient with hepatitis C virus.
May 2019, CEN case reports,
J W Fang, and F Y Tung, and G L Davis, and D J Dolson, and D H Van Thiel, and J Y Lau
Fatal reactivation of precore mutant hepatitis B virus associated with fibrosing cholestatic hepatitis after bone marrow transplantation.
August 1994, Annals of internal medicine,
J W Fang, and F Y Tung, and G L Davis, and D J Dolson, and D H Van Thiel, and J Y Lau
Hepatitis C virus-related fibrosing cholestatic hepatitis in a renal transplant recipient.
January 2006, Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology,
J W Fang, and F Y Tung, and G L Davis, and D J Dolson, and D H Van Thiel, and J Y Lau
Fibrosing cholestatic hepatitis in a liver transplant recipient with hepatitis C virus infection: a case report.
February 2003, Transplantation proceedings,
J W Fang, and F Y Tung, and G L Davis, and D J Dolson, and D H Van Thiel, and J Y Lau
Fibrosing cholestatic hepatitis-like syndrome in a hepatitis B virus and hepatitis C virus-negative renal transplant recipient: a case report with autopsy findings.
January 2003, Tropical gastroenterology : official journal of the Digestive Diseases Foundation,
J W Fang, and F Y Tung, and G L Davis, and D J Dolson, and D H Van Thiel, and J Y Lau
Fatal hepatitis C in a renal transplant recipient on immunosuppression: fibrosing cholestatic hepatitis.
June 2012, Journal of clinical and experimental hepatology,
J W Fang, and F Y Tung, and G L Davis, and D J Dolson, and D H Van Thiel, and J Y Lau
Fibrosing cholestatic hepatitis in renal transplant recipient with CMV infection: a case report.
January 2004, International urology and nephrology,
J W Fang, and F Y Tung, and G L Davis, and D J Dolson, and D H Van Thiel, and J Y Lau
Fibrosing cholestatic hepatitis in renal transplant recipients with hepatitis C virus infection.
July 1999, Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society,
J W Fang, and F Y Tung, and G L Davis, and D J Dolson, and D H Van Thiel, and J Y Lau
Fulminant hepatic failure in a renal transplant recipient with positive hepatitis B surface antigens: a case report of fibrosing cholestatic hepatitis.
January 1995, Hepato-gastroenterology,
Copied contents to your clipboard!