-transparent.png){kind=logo}
3-Fluorinated quinoline (3FQ), a non-mutagenic derivative of the potent mutagen quinoline, was metabolized with a microsomal enzyme fraction isolated from the 3-methylcholanthrene-treated rat liver. The metabolites were 3-fluoro-5,6-dihydroquinoline-5,6-trans-diol (72%), 3-fluoroquinoline 1-oxide (6%), 3-fluoro-5,6-dihydroquinoline-5,6-cis-epoxide (1%), and 4 unidentified metabolites (11%). Since this metabolic pattern is similar to that obtained with unfluorinated quinoline, the epoxidation of the benzene moieties of quinoline and 3-fluoroquinoline is most likely a detoxication process and not mutagenic activation.
Related Publications
K Saeki, and
K Takahashi, and
Y Kawazoe
February 1999,
Mutation research,
K Saeki, and
K Takahashi, and
Y Kawazoe
November 1988,
Chemical & pharmaceutical bulletin,
K Saeki, and
K Takahashi, and
Y Kawazoe
January 1989,
Drug metabolism and disposition: the biological fate of chemicals,
K Saeki, and
K Takahashi, and
Y Kawazoe
January 1995,
Archives of toxicology,
K Saeki, and
K Takahashi, and
Y Kawazoe
October 1993,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
K Saeki, and
K Takahashi, and
Y Kawazoe
July 1987,
Carcinogenesis,
K Saeki, and
K Takahashi, and
Y Kawazoe
October 1998,
Carcinogenesis,
K Saeki, and
K Takahashi, and
Y Kawazoe
March 1984,
Mutation research,
K Saeki, and
K Takahashi, and
Y Kawazoe
February 1987,
Mutation research,
K Saeki, and
K Takahashi, and
Y Kawazoe
March 1988,
Carcinogenesis,
