Biomaterial Database

[Polypoid malignant melanoma. An aggressive, seldom observed variant of nodular malignant melanoma]. 1993

M Megahed, and U Hoffmann, and M Flür, and E Hölzle

Hautklinik Heinrich-Heine-Universität Düsseldorf.

We describe a 54-year-old man with a polypoid melanoma. The tumour had developed within 1 year. Physical examination showed an eroded pedunculated nodule approximately 2.5 x 3 cm in size. Histopathology revealed a pedunculated, sharply demarcated tumour with an eroded surface; it was composed of atypical melanocytes in sheets and nests. Physical examination 11 months after excision of the tumor with 3-cm safety margin disclosed no evidence for enlarged lymph nodes or cutaneous metastases. No metastases were seen on computer tomography. To our knowledge, this patient represents the first case of polypoid melanoma reported in the German literature.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008544	Melanocytes	Mammalian pigment cells that produce MELANINS, pigments found mainly in the EPIDERMIS, but also in the eyes and the hair, by a process called melanogenesis. Coloration can be altered by the number of melanocytes or the amount of pigment produced and stored in the organelles called MELANOSOMES. The large non-mammalian melanin-containing cells are called MELANOPHORES.	Melanocyte
D008545	Melanoma	A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	Malignant Melanoma,Malignant Melanomas,Melanoma, Malignant,Melanomas,Melanomas, Malignant
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D003937	Diagnosis, Differential	Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures.	Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001706	Biopsy	Removal and pathologic examination of specimens from the living body.	Biopsies
D012867	Skin	The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D012878	Skin Neoplasms	Tumors or cancer of the SKIN.	Cancer of Skin,Skin Cancer,Cancer of the Skin,Neoplasms, Skin,Cancer, Skin,Cancers, Skin,Neoplasm, Skin,Skin Cancers,Skin Neoplasm