Biomaterial Database

The pharmacokinetics of metabolism of inhalation anaesthetics. A simulation study. 1977

A Feingold, and D A Holaday

The non-steady state metabolism of inhalation anaesthetics during anaesthesia and recovery was simulated with a linear and non-linear whole body compartmental model. These two models were studied for nine anaesthetics during 1-MAC anaesthesias lasting 1, 4 and 8 h and recovery from 5 to 10 days. Both models demonstrated significant metabolism for several days following anaesthesia. For the linear model, both the percentage and the molar quantity of anaesthetic metabolized increased with increased duration of anaesthesia, increased anaesthetic fat solubility and increased assumed rate of hepatic metabolism. For the non-linear model, the duration of anaesthesia had little effect on the percentage metabolized but demonstrated increased molar quantities of anaesthetic metabolized with increased duration of anaesthesia and increased fat solubility. The agreement between the results obtained from the non-linear model and experimental data in the literature suggests that many inhalation anaesthetics belong to a class of xenobiotics whose biotransformation is limited by the same or similar non-linear rate-limiting step(s). A difference in the quantities of anaesthetic metabolized would be a direct consequence of the tissue solubilities of the anaesthetic.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D003201	Computers	Programmable electronic devices designed to accept data, perform prescribed mathematical and logical operations at high speed, and display the results of these operations.	Calculators, Programmable,Computer Hardware,Computers, Digital,Hardware, Computer,Calculator, Programmable,Computer,Computer, Digital,Digital Computer,Digital Computers,Programmable Calculator,Programmable Calculators
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000769	Anesthesia, Inhalation	Anesthesia caused by the breathing of anesthetic gases or vapors or by insufflating anesthetic gases or vapors into the respiratory tract.	Insufflation Anesthesia,Anesthesia, Insufflation,Inhalation Anesthesia
D000777	Anesthetics	Agents capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.	Anesthetic,Anesthetic Agents,Anesthetic Drugs,Anesthetic Effect,Anesthetic Effects,Agents, Anesthetic,Drugs, Anesthetic,Effect, Anesthetic,Effects, Anesthetic
D012995	Solubility	The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Solubilities