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Contractions were elicited by field stimulation and norepinephrine in canine cutaneous arteries in Krebs-bicarbonate and Krebs-Tris media and the effect of angiotensin II, 1 x 10(-7) M, on these responses was determined. The absolute magnitude of the field stimulation responses was much greater in the bicarbonate buffer. Angiotensin caused potentiation in both media of the responses to field stimulation and norepinephrine. In Triss buffer with 5 mM calcium the responses to field stimulation and norepinephrine were greater than in 2.5 mM calcium, however; the degree of potentiation caused by angiotensin was similar at both calcium concentrations. The angiotensin potentiating effect in vitro appears to involve a postsynaptic action of the polypeptide which is not affected by alteration of calcium concentration or the medium.
K M Povolny, and
R W Jung, and
E Kraft, and
B G Zimmerman
May 2001,
Journal of cardiovascular pharmacology,
K M Povolny, and
R W Jung, and
E Kraft, and
B G Zimmerman
December 1986,
The Tohoku journal of experimental medicine,
K M Povolny, and
R W Jung, and
E Kraft, and
B G Zimmerman
June 1993,
The British journal of radiology,
K M Povolny, and
R W Jung, and
E Kraft, and
B G Zimmerman
November 1992,
The British journal of radiology,
K M Povolny, and
R W Jung, and
E Kraft, and
B G Zimmerman
July 1990,
The American journal of physiology,
K M Povolny, and
R W Jung, and
E Kraft, and
B G Zimmerman
December 1984,
Japanese journal of pharmacology,
K M Povolny, and
R W Jung, and
E Kraft, and
B G Zimmerman
March 1993,
Stroke,
K M Povolny, and
R W Jung, and
E Kraft, and
B G Zimmerman
September 2003,
Clinical and experimental pharmacology & physiology,
K M Povolny, and
R W Jung, and
E Kraft, and
B G Zimmerman
January 1980,
Hypertension (Dallas, Tex. : 1979),
K M Povolny, and
R W Jung, and
E Kraft, and
B G Zimmerman
January 1976,
Circulation research,
