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40 patients with inoperable, histologically proved carcinoma of the prostate were treated with estramustine phosphate. 35 patients had progressive, symptomatic, metastatic disease unresponsive to conventional oestrogens and/or castration Estramustine phosphate was given intravenously initially at a dose of 150 mg/day increasing to 300 mg/day. After 3 weeks or more oral therapy was substituted in 23 patients at a dose of 560 mg/day. Of 23 evaluable patients given the drug by both routes, 17 died after a mean treatment period of 12.5 months and 6 are alive and well after a mean treatment period of 27.7 months. The cause of death in 2 patients was probably, and in a third certainly, due to myocardial infarction. The other 31 deaths were due to carcinoma of the prostate. 18 patients showed transient toxic side-effects. No haematological abnormalities were found during treatment. An attempt at active treatment with estramustine phosphate in patients with prostatic cancer is justified when the disease is resistant to treatment with conventional oestrogens.
R Nagel, and
C P Köllin
April 1976,
The Journal of urology,
R Nagel, and
C P Köllin
January 1984,
Actas urologicas espanolas,
R Nagel, and
C P Köllin
January 1977,
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R Nagel, and
C P Köllin
November 1976,
New York state journal of medicine,
R Nagel, and
C P Köllin
June 1981,
Clinical oncology,
R Nagel, and
C P Köllin
January 1977,
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R Nagel, and
C P Köllin
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R Nagel, and
C P Köllin
July 1974,
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R Nagel, and
C P Köllin
April 1979,
The Journal of urology,
R Nagel, and
C P Köllin
January 1977,
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer,
