-transparent.png){kind=logo}
The purpose of this study was to evaluate liposome-encapsulated hemoglobin, named Neo Red Cells (NRC), on hemodynamics and oxygen-transport capacity in a blood exchange experiment. The experiment was carried out in nine mongrel dogs. Depending on the percentage of blood exchange with NRC, the animals were divided into two groups; Group I (4 animals with an exchange rate less than 88%), and Group II (5 animals with an exchange rate over 88%). After blood exchange, total peripheral vascular resistance index (TPRI) decreased and cardiac index (CI) increased. These changes were more marked in Group II than in Group I, thus showing that NRC relieved the burden on the heart, probably due to the fact that the viscosity of NRC is 2 cp which is less than 1/3 that of whole blood. The oxygen binding capacity per 1g hemoglobin in NRC was 2-4 times as much as red blood cells. Thus, NRC was superior to natural red blood cells in terms of oxygen transport capacity and its effects on the circulatory system.
A Usuba, and
M Miyazawa, and
R Motoki, and
K Sakaguchi, and
K Suzuki, and
T Kamitani, and
A Takahashi
January 1992,
Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology,
A Usuba, and
M Miyazawa, and
R Motoki, and
K Sakaguchi, and
K Suzuki, and
T Kamitani, and
A Takahashi
November 1998,
Artificial cells, blood substitutes, and immobilization biotechnology,
A Usuba, and
M Miyazawa, and
R Motoki, and
K Sakaguchi, and
K Suzuki, and
T Kamitani, and
A Takahashi
January 1998,
The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi,
A Usuba, and
M Miyazawa, and
R Motoki, and
K Sakaguchi, and
K Suzuki, and
T Kamitani, and
A Takahashi
July 1997,
Artificial cells, blood substitutes, and immobilization biotechnology,
A Usuba, and
M Miyazawa, and
R Motoki, and
K Sakaguchi, and
K Suzuki, and
T Kamitani, and
A Takahashi
January 1994,
Artificial cells, blood substitutes, and immobilization biotechnology,
A Usuba, and
M Miyazawa, and
R Motoki, and
K Sakaguchi, and
K Suzuki, and
T Kamitani, and
A Takahashi
January 1974,
Journal of medicine,
A Usuba, and
M Miyazawa, and
R Motoki, and
K Sakaguchi, and
K Suzuki, and
T Kamitani, and
A Takahashi
January 1984,
Acta diabetologica latina,
A Usuba, and
M Miyazawa, and
R Motoki, and
K Sakaguchi, and
K Suzuki, and
T Kamitani, and
A Takahashi
June 2012,
Artificial cells, blood substitutes, and immobilization biotechnology,
A Usuba, and
M Miyazawa, and
R Motoki, and
K Sakaguchi, and
K Suzuki, and
T Kamitani, and
A Takahashi
December 2020,
International journal of molecular sciences,
A Usuba, and
M Miyazawa, and
R Motoki, and
K Sakaguchi, and
K Suzuki, and
T Kamitani, and
A Takahashi
September 2001,
Artificial cells, blood substitutes, and immobilization biotechnology,
