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In order to evaluate the possible effects of delta-9-tetrahydrocannabinol (THC) on autonomic nervous system function, cardiovascular responses to intravenous isoproterenol, phenylephrine, atropine, and propranolol were compared in hospitalized volunteers before and after 14 days of THC ingestion. There was no significant alteration in responses to isoproterenol or phenylephrine, although in one subject the pressor effect of phenylephrine was considerably augmented by THC. Heart rates after parasympathetic (atropine) blockade and after combined parasympathetic and sympathetic (propranolol) blockade were significantly greater during THC ingestion. These and other data presented are consistent with the picture of reduced sympathetic and enhanced parasympathetic activity described in animals on THC. During THC ingestion, atropine had a pronounced pressor effect, which might represent a clinically significant drug interaction.
N L Benowitz, and
R T Jones
October 2007,
PLoS biology,
N L Benowitz, and
R T Jones
January 1983,
Psychopharmacology,
N L Benowitz, and
R T Jones
June 1978,
Research communications in chemical pathology and pharmacology,
N L Benowitz, and
R T Jones
May 1975,
Clinical pharmacology and therapeutics,
N L Benowitz, and
R T Jones
April 1993,
Neuropharmacology,
N L Benowitz, and
R T Jones
March 1973,
Lebensversicherungs Medizin,
N L Benowitz, and
R T Jones
February 1981,
The Journal of pharmacology and experimental therapeutics,
N L Benowitz, and
R T Jones
June 1973,
Life sciences,
N L Benowitz, and
R T Jones
November 1986,
Neuropharmacology,
N L Benowitz, and
R T Jones
December 1973,
Life sciences,
