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A 45-year-old diabetic man had aortic valve replacement for Candida glabrata endocarditis. Postoperatively he was treated with fluconazole and amphotericin B. Despite therapy, C. glabrata was isolated from his blood. He collapsed suddenly and died of heart failure 70 days after operation. Autopsy revealed suture line insufficiency and perivalvular leakage. On histologic examination many colonies of fungi were found in the aortic valvular annulus and an embolus to the mesenteric artery.
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