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The study was undertaken to elucidate the role of hemostatic parameters versus clinical data in the development of myocardial infarction and cardiac death. A total of 56 patients who suffered from angiographically documented coronary heart disease were examined. In addition to coronary angiography, bicycle ergometry, blood lipid measurements performed, the authors measured the levels of fibrinogen (FG), C protein, plasminogen, antiplasmin, fibrinogen/fibrin degradation products, tissue plasminogen activator (TPA) in venous occlusion, its inhibitor. The follow-up averaged 718 +/- 32.4 days. Nine patients developed large myocardial infarction, 6 died. In patients with poor prognosis, the baseline levels of FG and TPA were significantly higher: 3.35 +/- 0.168 and 2.73 +/- 0.79 g/l (P = 0.007) and 129.3 +/- 67.8 +/- 6.5 IU/ml (p = 0.049), respectively. A multifactorial discriminant analysis showed that TPA was the first to be of prognostic value in predicting the unfavourable prognosis, whereas FG and the number of coronary arteries with more than 70% narrowing and cholesterol levels were the second, third, and fourth. Thus, it was found that in addition to the levels of cholesterol and the number of diseased coronary arteries, the levels of TPA and FG appeared to be the most significant determinants of a patient's prognosis.
D A Zateĭshchikov, and
O V Averkov, and
A D Deev, and
A B Dobrovol'skiĭ, and
Iu A Zuĭnov, and
D V Istrin, and
N A Gratsianskiĭ
September 1985,
Kardiologiia,
D A Zateĭshchikov, and
O V Averkov, and
A D Deev, and
A B Dobrovol'skiĭ, and
Iu A Zuĭnov, and
D V Istrin, and
N A Gratsianskiĭ
January 2006,
Pathophysiology of haemostasis and thrombosis,
D A Zateĭshchikov, and
O V Averkov, and
A D Deev, and
A B Dobrovol'skiĭ, and
Iu A Zuĭnov, and
D V Istrin, and
N A Gratsianskiĭ
January 2002,
Kardiologiia,
D A Zateĭshchikov, and
O V Averkov, and
A D Deev, and
A B Dobrovol'skiĭ, and
Iu A Zuĭnov, and
D V Istrin, and
N A Gratsianskiĭ
May 1988,
Kardiologiia,
D A Zateĭshchikov, and
O V Averkov, and
A D Deev, and
A B Dobrovol'skiĭ, and
Iu A Zuĭnov, and
D V Istrin, and
N A Gratsianskiĭ
September 1974,
American heart journal,
D A Zateĭshchikov, and
O V Averkov, and
A D Deev, and
A B Dobrovol'skiĭ, and
Iu A Zuĭnov, and
D V Istrin, and
N A Gratsianskiĭ
September 1984,
Kardiologiia,
D A Zateĭshchikov, and
O V Averkov, and
A D Deev, and
A B Dobrovol'skiĭ, and
Iu A Zuĭnov, and
D V Istrin, and
N A Gratsianskiĭ
December 1987,
Orvosi hetilap,
D A Zateĭshchikov, and
O V Averkov, and
A D Deev, and
A B Dobrovol'skiĭ, and
Iu A Zuĭnov, and
D V Istrin, and
N A Gratsianskiĭ
January 1987,
Vestnik Akademii meditsinskikh nauk SSSR,
D A Zateĭshchikov, and
O V Averkov, and
A D Deev, and
A B Dobrovol'skiĭ, and
Iu A Zuĭnov, and
D V Istrin, and
N A Gratsianskiĭ
January 2013,
Advances in gerontology = Uspekhi gerontologii,
D A Zateĭshchikov, and
O V Averkov, and
A D Deev, and
A B Dobrovol'skiĭ, and
Iu A Zuĭnov, and
D V Istrin, and
N A Gratsianskiĭ
January 1995,
Journal of thrombosis and thrombolysis,
