Biomaterial Database

Experimentally produced pulmonary arterial occlusion in the dog: identification with pertechnegas inhalation. 1993

E M Scalzetti, and Z D Grossman, and G M Gagne

Department of Radiology, State University of New York, Syracuse 13210.

Pertechnegas, a variant of technegas, is a fine, dry aerosol formed when technetium-99m pertechnetate is vaporized in a technegas generator under appropriate conditions. After inhalation, the aerosol is deposited almost entirely on the surfaces of terminal respiratory structures. Unlike technegas, however, pertechnegas crosses the alveolar-capillary membrane and leaves the lung through the pulmonary circulation. To demonstrate prolonged retention of pertechnegas in regions of lung supplied by an occluded pulmonary artery, 12 pulmonary arterial occlusions were experimentally produced in two dogs. After inhalation of pertechnegas, a transient focus of increased pulmonary radioactivity was seen in 11 occlusions; 10 of these 11 foci were easily confirmed by means of subsequent perfusion scintigraphy. All 11 foci of retained pertechnegas corresponded to the location of the non-perfused lung. Thus, it is possible to identify ischemic lung with focal retention of pertechnegas (a finding that indicates preserved ventilation but diminished perfusion) by use of a single examination.

UI	MeSH Term	Description	Entries
D011651	Pulmonary Artery	The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.	Arteries, Pulmonary,Artery, Pulmonary,Pulmonary Arteries
D011877	Radionuclide Imaging	The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.	Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D000336	Aerosols	Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.	Aerosol
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001157	Arterial Occlusive Diseases	Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.	Arterial Obstructive Diseases,Arterial Occlusion,Arterial Obstructive Disease,Arterial Occlusions,Arterial Occlusive Disease,Disease, Arterial Obstructive,Disease, Arterial Occlusive,Obstructive Disease, Arterial,Occlusion, Arterial,Occlusive Disease, Arterial
D013670	Sodium Pertechnetate Tc 99m	A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, cardiovascular and cerebral circulation, brain, thyroid, and joints.	Pertechnetate Sodium,Tc 99m-Pertechnetate,Technetium Tc 99m Pertechnetate,99Tc-Pertechnetate,99TcmO4,99mTcO4,Pertechnetate,Technetium Pertechnetate,Technetium Tc 99m O(4),Technetium-99mTc-pertechnetate,99Tc Pertechnetate,99m-Pertechnetate, Tc,Pertechnetate, Technetium,Sodium, Pertechnetate,Tc 99m Pertechnetate,Technetium 99mTc pertechnetate