Biomaterial Database

Plasmacytoid monomorphic adenoma of salivary glands. Absence of myogenous differentiation and comparison to spindle cell myoepithelioma. 1993

D W Franquemont, and S E Mills

Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908.

The immunohistochemical and ultrastructural features of two salivary gland monomorphic adenomas composed of plasmacytoid cells (so-called plasmacytoid myoepitheliomas) were studied to determine if the plasmacytoid cells contained detectable evidence of myogenous differentiation. The results were compared with the immunohistochemical profile of three salivary gland myoepitheliomas of spindle-cell type. The plasmacytoid tumors were each immunoreactive for vimentin, cytokeratin, S100 protein, and glial fibrillary acidic protein (GFAP). They were negative for muscle-specific actin (MSA), smooth-muscle actin (SMA), and desmin. Conversely, two of three spindle-cell myoepitheliomas were immunoreactive for MSA and SMA, in addition to vimentin, cytokeratin, and S100 protein. One tumor also contained focal positivity for desmin and GFAP, and a single spindle-cell tumor was vimentin-positive only. Ultrastructurally, plasmacytoid cells were characterized by focal desmosomes, basal lamina, and abundant intermediate cytoplasmic filaments. Dense bodies typical of smooth-muscle cells and actin-sized filaments were absent. Immunohistochemically and ultra-structurally, the plasmacytoid cells lack any evidence of myogenous differentiation and should not be considered a subtype of myoepithelioma.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D009208	Myoepithelioma	A usually benign tumor made up predominantly of myoepithelial cells.	Myoepithelial Tumor,Myoepithelial Tumors,Myoepitheliomas,Tumor, Myoepithelial,Tumors, Myoepithelial
D002454	Cell Differentiation	Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.	Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000236	Adenoma	A benign epithelial tumor with a glandular organization.	Adenoma, Basal Cell,Adenoma, Follicular,Adenoma, Microcystic,Adenoma, Monomorphic,Adenoma, Papillary,Adenoma, Trabecular,Adenomas,Adenomas, Basal Cell,Adenomas, Follicular,Adenomas, Microcystic,Adenomas, Monomorphic,Adenomas, Papillary,Adenomas, Trabecular,Basal Cell Adenoma,Basal Cell Adenomas,Follicular Adenoma,Follicular Adenomas,Microcystic Adenoma,Microcystic Adenomas,Monomorphic Adenoma,Monomorphic Adenomas,Papillary Adenoma,Papillary Adenomas,Trabecular Adenoma,Trabecular Adenomas
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths