-transparent.png){kind=logo}
OBJECTIVE To compare the effects of placebo and GLA on the course of mild diabetic neuropathy over 1 yr. METHODS We entered 111 patients with mild diabetic neuropathy from seven centers into a randomized, double-blind, placebo-controlled parallel study of GLA at a dose of 480 mg/day. MNCV, SNAP, CMAP, hot and cold thresholds, sensation, tendon reflexes, and muscle strength were assessed by standard tests in upper and lower limbs. RESULTS For all 16 parameters, the change over 1 yr in response to GLA was more favorable than the change with placebo, and for 13 parameters, the difference was statistically significant. Sex, age, and type of diabetes did not influence the result, but treatment was more effective in relatively well-controlled than in poorly-controlled diabetic patients. CONCLUSIONS GLA had a beneficial effect on the course of diabetic neuropathy.
H Keen, and
J Payan, and
J Allawi, and
J Walker, and
G A Jamal, and
A I Weir, and
L M Henderson, and
E A Bissessar, and
P J Watkins, and
M Sampson
September 1993,
Diabetes care,
H Keen, and
J Payan, and
J Allawi, and
J Walker, and
G A Jamal, and
A I Weir, and
L M Henderson, and
E A Bissessar, and
P J Watkins, and
M Sampson
May 1986,
Lancet (London, England),
H Keen, and
J Payan, and
J Allawi, and
J Walker, and
G A Jamal, and
A I Weir, and
L M Henderson, and
E A Bissessar, and
P J Watkins, and
M Sampson
January 1992,
Agents and actions. Supplements,
H Keen, and
J Payan, and
J Allawi, and
J Walker, and
G A Jamal, and
A I Weir, and
L M Henderson, and
E A Bissessar, and
P J Watkins, and
M Sampson
March 1994,
Diabetic medicine : a journal of the British Diabetic Association,
H Keen, and
J Payan, and
J Allawi, and
J Walker, and
G A Jamal, and
A I Weir, and
L M Henderson, and
E A Bissessar, and
P J Watkins, and
M Sampson
May 1990,
Diabetic medicine : a journal of the British Diabetic Association,
H Keen, and
J Payan, and
J Allawi, and
J Walker, and
G A Jamal, and
A I Weir, and
L M Henderson, and
E A Bissessar, and
P J Watkins, and
M Sampson
July 1998,
Diabetologia,
H Keen, and
J Payan, and
J Allawi, and
J Walker, and
G A Jamal, and
A I Weir, and
L M Henderson, and
E A Bissessar, and
P J Watkins, and
M Sampson
January 1992,
Journal of diabetes and its complications,
H Keen, and
J Payan, and
J Allawi, and
J Walker, and
G A Jamal, and
A I Weir, and
L M Henderson, and
E A Bissessar, and
P J Watkins, and
M Sampson
January 1993,
Prostaglandins, leukotrienes, and essential fatty acids,
H Keen, and
J Payan, and
J Allawi, and
J Walker, and
G A Jamal, and
A I Weir, and
L M Henderson, and
E A Bissessar, and
P J Watkins, and
M Sampson
January 1983,
Acta diabetologica latina,
H Keen, and
J Payan, and
J Allawi, and
J Walker, and
G A Jamal, and
A I Weir, and
L M Henderson, and
E A Bissessar, and
P J Watkins, and
M Sampson
January 1993,
Diabetic medicine : a journal of the British Diabetic Association,
