Angiotensin I-converting enzyme activity in rats with carbon tetrachloride-induced acute renal failure. 1993

J Pedraza-Chaverrí, and C Cruz, and R Hernández-Pando, and T Santana, and A E Arévalo, and L González, and E Tapia, and J C Peña, and A Panduro
Department of Nephrology and Mineral Metabolism, Instituto Nacional de la Nutrición Salvador Zubirán, México D.F.

The angiotensin I-converting enzyme (ACE) activity was measured in urine, serum, and tissues from rats with carbon tetrachloride (CCl4)-induced acute renal failure on days 1, 2, 3, and 7 after CCl4 administration. Serum ACE increased on days 1 to 3. Heart, lung, small intestine, brain, and testis ACE decreased, whereas kidney and liver ACE remained unchanged. Urine ACE activity increased from day 1 to day 3. Our data suggest that the increase in serum ACE may be secondary to the ACE release from the damaged tissues, and that the urine ACE increase may be due to the kidney proximal tubule damage. This work supports the contention that an increase in urine ACE may be an indicator of damage to the proximal tubule.

UI MeSH Term Description Entries
D007687 Kidney Tubules, Proximal The renal tubule portion that extends from the BOWMAN CAPSULE in the KIDNEY CORTEX into the KIDNEY MEDULLA. The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE. Proximal Kidney Tubule,Proximal Renal Tubule,Kidney Tubule, Proximal,Proximal Kidney Tubules,Proximal Renal Tubules,Renal Tubule, Proximal,Renal Tubules, Proximal,Tubule, Proximal Kidney,Tubule, Proximal Renal,Tubules, Proximal Kidney,Tubules, Proximal Renal
D007703 Peptidyl-Dipeptidase A A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of ANGIOTENSIN I to ANGIOTENSIN II, with increase in vasoconstrictor activity, but no action on angiotensin II. It is also able to inactivate BRADYKININ, a potent vasodilator; and has a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. (From https://www.uniprot.org April 15, 2020). ACE1 Angiotensin-Converting Enzyme 1,ACE1 Protein,Angiotensin Converting Enzyme,Angiotensin Converting Enzyme 1,Antigens, CD143,CD143 Antigens,Dipeptidyl Carboxypeptidase I,Kininase II,Peptidase P,Angiotensin I-Converting Enzyme,Carboxycathepsin,Dipeptidyl Peptidase A,Kininase A,ACE1 Angiotensin Converting Enzyme 1,Angiotensin I Converting Enzyme,Carboxypeptidase I, Dipeptidyl,Peptidyl Dipeptidase A
D008297 Male Males
D002252 Carbon Tetrachloride Poisoning Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE. CCl4 Poisoning,Poisoning, CCl4,Poisoning, Carbon Tetrachloride,CCl4 Poisonings,Carbon Tetrachloride Poisonings,Poisonings, Carbon Tetrachloride
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D058186 Acute Kidney Injury Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions. Acute Kidney Failure,Acute Kidney Insufficiency,Acute Renal Failure,Acute Renal Injury,Acute Renal Insufficiency,Kidney Failure, Acute,Kidney Insufficiency, Acute,Renal Failure, Acute,Renal Insufficiency, Acute,Acute Kidney Failures,Acute Kidney Injuries,Acute Kidney Insufficiencies,Acute Renal Failures,Acute Renal Injuries,Acute Renal Insufficiencies,Kidney Failures, Acute,Kidney Injuries, Acute,Kidney Injury, Acute,Kidney Insufficiencies, Acute,Renal Failures, Acute,Renal Injuries, Acute,Renal Injury, Acute,Renal Insufficiencies, Acute

Related Publications

J Pedraza-Chaverrí, and C Cruz, and R Hernández-Pando, and T Santana, and A E Arévalo, and L González, and E Tapia, and J C Peña, and A Panduro
April 2006, Zhonghua er ke za zhi = Chinese journal of pediatrics,
J Pedraza-Chaverrí, and C Cruz, and R Hernández-Pando, and T Santana, and A E Arévalo, and L González, and E Tapia, and J C Peña, and A Panduro
September 1988, Kidney international,
J Pedraza-Chaverrí, and C Cruz, and R Hernández-Pando, and T Santana, and A E Arévalo, and L González, and E Tapia, and J C Peña, and A Panduro
September 1994, Clinical nephrology,
J Pedraza-Chaverrí, and C Cruz, and R Hernández-Pando, and T Santana, and A E Arévalo, and L González, and E Tapia, and J C Peña, and A Panduro
January 2008, Annals of hepatology,
J Pedraza-Chaverrí, and C Cruz, and R Hernández-Pando, and T Santana, and A E Arévalo, and L González, and E Tapia, and J C Peña, and A Panduro
December 1993, Toxicology,
J Pedraza-Chaverrí, and C Cruz, and R Hernández-Pando, and T Santana, and A E Arévalo, and L González, and E Tapia, and J C Peña, and A Panduro
September 1998, Harefuah,
J Pedraza-Chaverrí, and C Cruz, and R Hernández-Pando, and T Santana, and A E Arévalo, and L González, and E Tapia, and J C Peña, and A Panduro
January 1991, Nephron,
J Pedraza-Chaverrí, and C Cruz, and R Hernández-Pando, and T Santana, and A E Arévalo, and L González, and E Tapia, and J C Peña, and A Panduro
February 1988, Experientia,
J Pedraza-Chaverrí, and C Cruz, and R Hernández-Pando, and T Santana, and A E Arévalo, and L González, and E Tapia, and J C Peña, and A Panduro
January 1991, The Journal of diabetic complications,
J Pedraza-Chaverrí, and C Cruz, and R Hernández-Pando, and T Santana, and A E Arévalo, and L González, and E Tapia, and J C Peña, and A Panduro
March 1996, Renal failure,
Copied contents to your clipboard!