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Dihydroagarofuran sesquiterpenes, which were isolated from Tripterygium wilfordii Hook fil. var. regelii Makino and Euonymus sieboldianus Blume, showed inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Triptogelin A-1, one of the active dihydroagarofuran sesquiterpenes, exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. Interestingly, triptogelin A-1 was more effective when applied after TPA-treatment (post-treatment) than before TPA-treatment (pretreatment). The findings indicate that these dihydroagarofuran sesquiterpenes might be valuable antitumor promoters.
K Ujita, and
Y Takaishi, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
March 1990,
Chemical & pharmaceutical bulletin,
K Ujita, and
Y Takaishi, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
March 1994,
Biological & pharmaceutical bulletin,
K Ujita, and
Y Takaishi, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
December 1986,
Cancer letters,
K Ujita, and
Y Takaishi, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
February 2014,
Food & function,
K Ujita, and
Y Takaishi, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
September 2019,
European journal of pharmacology,
K Ujita, and
Y Takaishi, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
March 2004,
Toxicology and applied pharmacology,
K Ujita, and
Y Takaishi, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
October 1995,
Carcinogenesis,
K Ujita, and
Y Takaishi, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
January 2007,
Biological & pharmaceutical bulletin,
K Ujita, and
Y Takaishi, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
July 2011,
Cancer prevention research (Philadelphia, Pa.),
K Ujita, and
Y Takaishi, and
H Tokuda, and
H Nishino, and
A Iwashima, and
T Fujita
July 1992,
Photochemistry and photobiology,
